European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 cas...

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Detalles Bibliográficos
Autores principales: Ho, Weang-Kee, Tan, Min-Min, Mavaddat, Nasim, Tai, Mei-Chee, Mariapun, Shivaani, Li, Jingmei, Ho, Peh-Joo, Dennis, Joe, Tyrer, Jonathan P., Bolla, Manjeet K., Michailidou, Kyriaki, Wang, Qin, Kang, Daehee, Choi, Ji-Yeob, Jamaris, Suniza, Shu, Xiao-Ou, Yoon, Sook-Yee, Park, Sue K., Kim, Sung-Won, Shen, Chen-Yang, Yu, Jyh-Cherng, Tan, Ern Yu, Chan, Patrick Mun Yew, Muir, Kenneth, Lophatananon, Artitaya, Wu, Anna H., Stram, Daniel O., Matsuo, Keitaro, Ito, Hidemi, Chan, Ching Wan, Ngeow, Joanne, Yong, Wei Sean, Lim, Swee Ho, Lim, Geok Hoon, Kwong, Ava, Chan, Tsun L., Tan, Su Ming, Seah, Jaime, John, Esther M., Kurian, Allison W., Koh, Woon-Puay, Khor, Chiea Chuen, Iwasaki, Motoki, Yamaji, Taiki, Tan, Kiak Mien Veronique, Tan, Kiat Tee Benita, Spinelli, John J., Aronson, Kristan J., Hasan, Siti Norhidayu, Rahmat, Kartini, Vijayananthan, Anushya, Sim, Xueling, Pharoah, Paul D. P., Zheng, Wei, Dunning, Alison M., Simard, Jacques, van Dam, Rob Martinus, Yip, Cheng-Har, Taib, Nur Aishah Mohd, Hartman, Mikael, Easton, Douglas F., Teo, Soo-Hwang, Antoniou, Antonis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395776/
https://www.ncbi.nlm.nih.gov/pubmed/32737321
http://dx.doi.org/10.1038/s41467-020-17680-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395776/
https://www.ncbi.nlm.nih.gov/pubmed/32737321
http://dx.doi.org/10.1038/s41467-020-17680-w

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