Cargando…

Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promotes Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer

The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nollet, Eric A., Cardo-Vila, Marina, Ganguly, Sourik S., Tran, Jack D., Schulz, Veronique V., Cress, Anne, Corey, Eva, Miranti, Cindy K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395876/ https://www.ncbi.nlm.nih.gov/pubmed/32565538 http://dx.doi.org/10.1038/s41388-020-1370-9

Ejemplares similares

Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase
por: Zarif, Jelani C., et al.
Publicado: (2015)

The Host Microenvironment Influences Prostate Cancer Invasion, Systemic Spread, Bone Colonization, and Osteoblastic Metastasis
por: Ganguly, Sourik S., et al.
Publicado: (2014)

Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1
por: Tesfay, Lia, et al.
Publicado: (2016)

Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion
por: Putnam, Andrew J, et al.
Publicado: (2009)

Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3
por: Ganguly, Sourik S., et al.
Publicado: (2019)

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer
por: Qi, Wenqing, et al.
Publicado: (2015)

Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer
por: Chuu, Chih-Pin, et al.
Publicado: (2011)

Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
por: Bergsma, Alexis, et al.
Publicado: (2019)

Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer
por: Montgomery, Bruce, et al.
Publicado: (2010)

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
por: Vianello, Caterina, et al.
Publicado: (2022)

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer
por: Stein, Mark N, et al.
Publicado: (2014)

Persistent androgen receptor addiction in castration-resistant prostate cancer
por: Schweizer, Michael T., et al.
Publicado: (2015)

The expression of AURKA is androgen regulated in castration-resistant prostate cancer
por: Kivinummi, Kati, et al.
Publicado: (2017)

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
por: Feng, Qin, et al.
Publicado: (2019)

DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming
por: Veron, Vincent, et al.
Publicado: (2018)

Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
por: Vianello, Caterina, et al.
Publicado: (2022)

Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
por: Vianello, Caterina, et al.
Publicado: (2023)

Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
por: Vianello, Caterina, et al.
Publicado: (2023)

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer
por: Zimmer, Brenna M., et al.
Publicado: (2021)

Cabozantinib Inhibits Growth of Androgen-Sensitive and Castration-Resistant Prostate Cancer and Affects Bone Remodeling
por: Nguyen, Holly M., et al.
Publicado: (2013)

Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L
por: Song, Chengli, et al.
Publicado: (2015)

The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
por: Gunter, Jennifer H., et al.
Publicado: (2012)

Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer
por: Perner, Sven, et al.
Publicado: (2015)

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer
por: Pollock, Julie A., et al.
Publicado: (2016)

Predicting castration-resistant prostate cancer after combined androgen blockade
por: He, Miao, et al.
Publicado: (2017)

Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer
por: Conteduca, Vincenza, et al.
Publicado: (2019)

Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer
por: Gritsina, Galina, et al.
Publicado: (2019)

Recent Discoveries in the Androgen Receptor Pathway in Castration-Resistant Prostate Cancer
por: Obinata, Daisuke, et al.
Publicado: (2020)

Integrin Involvement in Freeze Resistance of Androgen-Insensitive Prostate Cancer
por: Baust, John G., et al.
Publicado: (2010)

Data of relative mRNA and protein abundances of androgen receptor splice variants in castration-resistant prostate cancer
por: Ma, Tianfang, et al.
Publicado: (2021)

Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers
por: Zhang, Ailin, et al.
Publicado: (2023)

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer
por: Kregel, Steven, et al.
Publicado: (2016)

Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer
por: Wu, Meng, et al.
Publicado: (2023)

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
por: Decker, Keith F., et al.
Publicado: (2012)

Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer
por: Cao, Subing, et al.
Publicado: (2019)

BNIP3 in Lung Cancer: To Kill or Rescue?
por: Gorbunova, Anna S., et al.
Publicado: (2020)

Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
por: Zhang, Xiaotun, et al.
Publicado: (2011)

Experimental Evidence of Persistent Androgen-Receptor-Dependency in Castration-Resistant Prostate Cancer
por: Kobayashi, Takashi, et al.
Publicado: (2013)

Abiraterone Acetate: Targeting Persistent Androgen Dependence in Castration-Resistant Prostate Cancer
por: Harshman, Lauren C., et al.
Publicado: (2013)

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer
por: Lallous, Nada, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4f74dc421akcvu0rroq2gui9go