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COVID-19 and diabetes mellitus: how one pandemic worsens the other

In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a highe...

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Autores principales: Azar, William S., Njeim, Rachel, Fares, Angie H., Azar, Nadim S., Azar, Sami T., El Sayed, Mazen, Eid, Assaad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395898/
https://www.ncbi.nlm.nih.gov/pubmed/32743793
http://dx.doi.org/10.1007/s11154-020-09573-6
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author Azar, William S.
Njeim, Rachel
Fares, Angie H.
Azar, Nadim S.
Azar, Sami T.
El Sayed, Mazen
Eid, Assaad A.
author_facet Azar, William S.
Njeim, Rachel
Fares, Angie H.
Azar, Nadim S.
Azar, Sami T.
El Sayed, Mazen
Eid, Assaad A.
author_sort Azar, William S.
collection PubMed
description In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease. The worsened prognosis of COVID-19 patients with DM can be attributed to a facilitated viral uptake assisted by the host’s receptor angiotensin-converting enzyme 2 (ACE2). It can also be associated with a higher basal level of pro-inflammatory cytokines present in patients with diabetes, which enables a hyperinflammatory “cytokine storm” in response to the virus. This review also suggests a link between elevated levels of IL-6 and AMPK/mTOR signaling pathway and their role in exacerbating diabetes-induced complications and insulin resistance. If further studied, these findings could help identify novel therapeutic intervention strategies for patients with diabetes comorbid with COVID-19.
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spelling pubmed-73958982020-08-03 COVID-19 and diabetes mellitus: how one pandemic worsens the other Azar, William S. Njeim, Rachel Fares, Angie H. Azar, Nadim S. Azar, Sami T. El Sayed, Mazen Eid, Assaad A. Rev Endocr Metab Disord Article In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease. The worsened prognosis of COVID-19 patients with DM can be attributed to a facilitated viral uptake assisted by the host’s receptor angiotensin-converting enzyme 2 (ACE2). It can also be associated with a higher basal level of pro-inflammatory cytokines present in patients with diabetes, which enables a hyperinflammatory “cytokine storm” in response to the virus. This review also suggests a link between elevated levels of IL-6 and AMPK/mTOR signaling pathway and their role in exacerbating diabetes-induced complications and insulin resistance. If further studied, these findings could help identify novel therapeutic intervention strategies for patients with diabetes comorbid with COVID-19. Springer US 2020-08-02 2020 /pmc/articles/PMC7395898/ /pubmed/32743793 http://dx.doi.org/10.1007/s11154-020-09573-6 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Azar, William S.
Njeim, Rachel
Fares, Angie H.
Azar, Nadim S.
Azar, Sami T.
El Sayed, Mazen
Eid, Assaad A.
COVID-19 and diabetes mellitus: how one pandemic worsens the other
title COVID-19 and diabetes mellitus: how one pandemic worsens the other
title_full COVID-19 and diabetes mellitus: how one pandemic worsens the other
title_fullStr COVID-19 and diabetes mellitus: how one pandemic worsens the other
title_full_unstemmed COVID-19 and diabetes mellitus: how one pandemic worsens the other
title_short COVID-19 and diabetes mellitus: how one pandemic worsens the other
title_sort covid-19 and diabetes mellitus: how one pandemic worsens the other
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395898/
https://www.ncbi.nlm.nih.gov/pubmed/32743793
http://dx.doi.org/10.1007/s11154-020-09573-6
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