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Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission

BACKGROUND: There are few reports of COVID-19 in neonates and most are suspected to be due to postnatal transmission. Vertical transmission has been proven in only a couple of cases so far. METHODS: We describe early—onset, severe COVID-19 disease in a neonate with very strong evidence of vertical t...

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Autores principales: Kulkarni, Rajesh, Rajput, Uday, Dawre, Rahul, Valvi, Chhaya, Nagpal, Rema, Magdum, Nikita, Vankar, Harshali, Sonkawade, Naresh, Das, Aiswarya, Vartak, Sagar, Joshi, Suvarna, Varma, Santosh, Karyakarte, Rajesh, Bhosale, Ramesh, Kinikar, Aarti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395939/
https://www.ncbi.nlm.nih.gov/pubmed/32743723
http://dx.doi.org/10.1007/s15010-020-01493-6
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author Kulkarni, Rajesh
Rajput, Uday
Dawre, Rahul
Valvi, Chhaya
Nagpal, Rema
Magdum, Nikita
Vankar, Harshali
Sonkawade, Naresh
Das, Aiswarya
Vartak, Sagar
Joshi, Suvarna
Varma, Santosh
Karyakarte, Rajesh
Bhosale, Ramesh
Kinikar, Aarti
author_facet Kulkarni, Rajesh
Rajput, Uday
Dawre, Rahul
Valvi, Chhaya
Nagpal, Rema
Magdum, Nikita
Vankar, Harshali
Sonkawade, Naresh
Das, Aiswarya
Vartak, Sagar
Joshi, Suvarna
Varma, Santosh
Karyakarte, Rajesh
Bhosale, Ramesh
Kinikar, Aarti
author_sort Kulkarni, Rajesh
collection PubMed
description BACKGROUND: There are few reports of COVID-19 in neonates and most are suspected to be due to postnatal transmission. Vertical transmission has been proven in only a couple of cases so far. METHODS: We describe early—onset, severe COVID-19 disease in a neonate with very strong evidence of vertical transmission of SARS-CoV-2. RESULTS: A COVID-19 suspected mother, who tested negative by RT-PCR for COVID, but tested positive for SARS-CoV-2 by serology, delivered a term baby. The neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on umbilical stump, placenta, and nasopharyngeal aspirate of the neonate, collected at birth were positive. On day 2, the neonate developed clinical features of COVID in the form of fever, poor feeding, and hyperbilirubenemia along with elevated inflammatory markers. Antibiotics were started empirically pending cultures. Blood, CSF, and urine cultures were sterile. Baby tested RT-PCR positive for SARS-CoV-2 on two more occasions before testing positive for antibodies and was discharged on day 21 of life. CONCLUSION: This report highlights a very strong possibility of vertical transmission of COVID-19 from a mildly symptomatic, RT-PCR negative but antibody-positive mother with significant symptomatic, early—onset neonatal infection.
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spelling pubmed-73959392020-08-03 Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission Kulkarni, Rajesh Rajput, Uday Dawre, Rahul Valvi, Chhaya Nagpal, Rema Magdum, Nikita Vankar, Harshali Sonkawade, Naresh Das, Aiswarya Vartak, Sagar Joshi, Suvarna Varma, Santosh Karyakarte, Rajesh Bhosale, Ramesh Kinikar, Aarti Infection Case Report BACKGROUND: There are few reports of COVID-19 in neonates and most are suspected to be due to postnatal transmission. Vertical transmission has been proven in only a couple of cases so far. METHODS: We describe early—onset, severe COVID-19 disease in a neonate with very strong evidence of vertical transmission of SARS-CoV-2. RESULTS: A COVID-19 suspected mother, who tested negative by RT-PCR for COVID, but tested positive for SARS-CoV-2 by serology, delivered a term baby. The neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on umbilical stump, placenta, and nasopharyngeal aspirate of the neonate, collected at birth were positive. On day 2, the neonate developed clinical features of COVID in the form of fever, poor feeding, and hyperbilirubenemia along with elevated inflammatory markers. Antibiotics were started empirically pending cultures. Blood, CSF, and urine cultures were sterile. Baby tested RT-PCR positive for SARS-CoV-2 on two more occasions before testing positive for antibodies and was discharged on day 21 of life. CONCLUSION: This report highlights a very strong possibility of vertical transmission of COVID-19 from a mildly symptomatic, RT-PCR negative but antibody-positive mother with significant symptomatic, early—onset neonatal infection. Springer Berlin Heidelberg 2020-08-02 2021 /pmc/articles/PMC7395939/ /pubmed/32743723 http://dx.doi.org/10.1007/s15010-020-01493-6 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Report
Kulkarni, Rajesh
Rajput, Uday
Dawre, Rahul
Valvi, Chhaya
Nagpal, Rema
Magdum, Nikita
Vankar, Harshali
Sonkawade, Naresh
Das, Aiswarya
Vartak, Sagar
Joshi, Suvarna
Varma, Santosh
Karyakarte, Rajesh
Bhosale, Ramesh
Kinikar, Aarti
Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title_full Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title_fullStr Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title_full_unstemmed Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title_short Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
title_sort early-onset symptomatic neonatal covid-19 infection with high probability of vertical transmission
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395939/
https://www.ncbi.nlm.nih.gov/pubmed/32743723
http://dx.doi.org/10.1007/s15010-020-01493-6
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