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Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature

Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multi...

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Autores principales: Vu, Ngoc Bao, Le, Ngoc Tuyen, Chaisuparat, Risa, Thunyakitpisal, Pasutha, Tran, Ngoc Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395988/
https://www.ncbi.nlm.nih.gov/pubmed/32774938
http://dx.doi.org/10.1155/2020/4072890
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author Vu, Ngoc Bao
Le, Ngoc Tuyen
Chaisuparat, Risa
Thunyakitpisal, Pasutha
Tran, Ngoc Minh
author_facet Vu, Ngoc Bao
Le, Ngoc Tuyen
Chaisuparat, Risa
Thunyakitpisal, Pasutha
Tran, Ngoc Minh
author_sort Vu, Ngoc Bao
collection PubMed
description Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multilocular, poorly defined, and mixed radiolucent-radiopaque lesion in the region of teeth #84 to #85, with bone and tooth root resorption. Computed tomography revealed buccal cortex destruction, tumor infiltration of soft tissue, and enlarged nodes. Incisional biopsy showed histomorphological features of AC. Immunohistochemical analysis exhibited a positive result for Cytokeratin (CK) 19 and overexpression of p53 and Ki67. The patient underwent right hemimandibulectomy and neck dissection. The final pathology was consistent with the initial diagnosis of AC. The patient did not exhibit signs of recurrence or metastasis within 2 years postoperatively. Given the rarity of this disease and the age of the patient, this report constitutes a valuable contribution to the current literature.
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spelling pubmed-73959882020-08-07 Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature Vu, Ngoc Bao Le, Ngoc Tuyen Chaisuparat, Risa Thunyakitpisal, Pasutha Tran, Ngoc Minh Case Rep Dent Case Report Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multilocular, poorly defined, and mixed radiolucent-radiopaque lesion in the region of teeth #84 to #85, with bone and tooth root resorption. Computed tomography revealed buccal cortex destruction, tumor infiltration of soft tissue, and enlarged nodes. Incisional biopsy showed histomorphological features of AC. Immunohistochemical analysis exhibited a positive result for Cytokeratin (CK) 19 and overexpression of p53 and Ki67. The patient underwent right hemimandibulectomy and neck dissection. The final pathology was consistent with the initial diagnosis of AC. The patient did not exhibit signs of recurrence or metastasis within 2 years postoperatively. Given the rarity of this disease and the age of the patient, this report constitutes a valuable contribution to the current literature. Hindawi 2020-07-22 /pmc/articles/PMC7395988/ /pubmed/32774938 http://dx.doi.org/10.1155/2020/4072890 Text en Copyright © 2020 Ngoc Bao Vu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vu, Ngoc Bao
Le, Ngoc Tuyen
Chaisuparat, Risa
Thunyakitpisal, Pasutha
Tran, Ngoc Minh
Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title_full Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title_fullStr Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title_full_unstemmed Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title_short Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
title_sort ameloblastic carcinoma in a 2-year-old child: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395988/
https://www.ncbi.nlm.nih.gov/pubmed/32774938
http://dx.doi.org/10.1155/2020/4072890
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