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Research Progress on NK Cell Receptors and Their Signaling Pathways
Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent signaling conduction and then determine wheth...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396059/ https://www.ncbi.nlm.nih.gov/pubmed/32774149 http://dx.doi.org/10.1155/2020/6437057 |
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author | Chen, Yingying Lu, Dan Churov, Alexey Fu, Rong |
author_facet | Chen, Yingying Lu, Dan Churov, Alexey Fu, Rong |
author_sort | Chen, Yingying |
collection | PubMed |
description | Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent signaling conduction and then determine whether NK is activated or inhibited. Furthermore, NK cell response includes cytotoxicity and cytokine release, which is tightly related to the activation of NK cell-activating receptors and the inhibition of inhibitory receptors on the surfaces of NK cells. The expression and function of NK cell surface receptors also alter in virus infection, tumor, and autoimmune diseases and influence the occurrence and development of diseases. So, it is important to understand the mechanism of recognition between NK receptors and their ligands in pathological conditions and the signaling pathways of NK cell receptors. This review mainly summarizes the research progress on NK cell surface receptors and their signal pathways. |
format | Online Article Text |
id | pubmed-7396059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73960592020-08-07 Research Progress on NK Cell Receptors and Their Signaling Pathways Chen, Yingying Lu, Dan Churov, Alexey Fu, Rong Mediators Inflamm Review Article Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent signaling conduction and then determine whether NK is activated or inhibited. Furthermore, NK cell response includes cytotoxicity and cytokine release, which is tightly related to the activation of NK cell-activating receptors and the inhibition of inhibitory receptors on the surfaces of NK cells. The expression and function of NK cell surface receptors also alter in virus infection, tumor, and autoimmune diseases and influence the occurrence and development of diseases. So, it is important to understand the mechanism of recognition between NK receptors and their ligands in pathological conditions and the signaling pathways of NK cell receptors. This review mainly summarizes the research progress on NK cell surface receptors and their signal pathways. Hindawi 2020-07-24 /pmc/articles/PMC7396059/ /pubmed/32774149 http://dx.doi.org/10.1155/2020/6437057 Text en Copyright © 2020 Yingying Chen et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Yingying Lu, Dan Churov, Alexey Fu, Rong Research Progress on NK Cell Receptors and Their Signaling Pathways |
title | Research Progress on NK Cell Receptors and Their Signaling Pathways |
title_full | Research Progress on NK Cell Receptors and Their Signaling Pathways |
title_fullStr | Research Progress on NK Cell Receptors and Their Signaling Pathways |
title_full_unstemmed | Research Progress on NK Cell Receptors and Their Signaling Pathways |
title_short | Research Progress on NK Cell Receptors and Their Signaling Pathways |
title_sort | research progress on nk cell receptors and their signaling pathways |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396059/ https://www.ncbi.nlm.nih.gov/pubmed/32774149 http://dx.doi.org/10.1155/2020/6437057 |
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