Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of c...

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Detalles Bibliográficos
Autores principales: Petrillo, Alessandra, Biran, Noa, Sadikot, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396067/
https://www.ncbi.nlm.nih.gov/pubmed/32774934
http://dx.doi.org/10.1155/2020/8832986
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author Petrillo, Alessandra
Biran, Noa
Sadikot, Sean
author_facet Petrillo, Alessandra
Biran, Noa
Sadikot, Sean
author_sort Petrillo, Alessandra
collection PubMed
description Acute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of care of ARDS, and current treatments at this time currently do not target the immunological mechanisms or pathways involved. Treatments involving this pathway should be further investigated as targeted treatment. We discuss a case of a patient with multiple myeloma who was hospitalized with drug-induced ARDS who had a rapid response to an anti-interleukin-6 monoclonal antibody.
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spelling pubmed-73960672020-08-07 Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome Petrillo, Alessandra Biran, Noa Sadikot, Sean Case Rep Crit Care Case Report Acute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of care of ARDS, and current treatments at this time currently do not target the immunological mechanisms or pathways involved. Treatments involving this pathway should be further investigated as targeted treatment. We discuss a case of a patient with multiple myeloma who was hospitalized with drug-induced ARDS who had a rapid response to an anti-interleukin-6 monoclonal antibody. Hindawi 2020-07-22 /pmc/articles/PMC7396067/ /pubmed/32774934 http://dx.doi.org/10.1155/2020/8832986 Text en Copyright © 2020 Alessandra Petrillo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Petrillo, Alessandra
Biran, Noa
Sadikot, Sean
Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title_full Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title_fullStr Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title_full_unstemmed Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title_short Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
title_sort use of anti-interleukin-6 receptor monoclonal antibody in drug-induced acute respiratory distress syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396067/
https://www.ncbi.nlm.nih.gov/pubmed/32774934
http://dx.doi.org/10.1155/2020/8832986
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