Anti-Diabetic Atherosclerosis by Inhibiting High Glucose-Induced Vascular Smooth Muscle Cell Proliferation via Pin1/BRD4 Pathway

METHODS: Diabetic Apoe-/- mice induced by streptozotocin were treated with vehicle, the Pin1 inhibitor juglone, or the BRD4 inhibitor JQ1 for 3 weeks. VSMCs were pretreated with juglone, JQ1, or vehicle for 45 min, and then exposed to high glucose for 48 h. Hematoxylin–eosin staining was performed t...

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Detalles Bibliográficos
Autores principales: Wu, Yuansheng, Zhang, Meijin, Xu, Changsheng, Chai, Dajun, Peng, Feng, Lin, Jinxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396119/
https://www.ncbi.nlm.nih.gov/pubmed/32774672
http://dx.doi.org/10.1155/2020/4196482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396119/
https://www.ncbi.nlm.nih.gov/pubmed/32774672
http://dx.doi.org/10.1155/2020/4196482

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