Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator

In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage progression, we profiled >56,000 V-SVZ and OB cells by single-cell RNA sequencing (scRNA-seq). Our analyses reveal the mo...

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Detalles Bibliográficos
Autores principales: Mizrak, Dogukan, Bayin, N. Sumru, Yuan, Jinzhou, Liu, Zhouzerui, Suciu, Radu M., Niphakis, Micah J., Ngo, Nhi, Lum, Kenneth M., Cravatt, Benjamin F., Joyner, Alexandra L., Sims, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396151/
https://www.ncbi.nlm.nih.gov/pubmed/32579931
http://dx.doi.org/10.1016/j.celrep.2020.107805

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