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Vascularization is the next challenge for skin tissue engineering as a solution for burn management
Skin regeneration represents a promising line of management for patients with skin loss, including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin const...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396265/ https://www.ncbi.nlm.nih.gov/pubmed/32766342 http://dx.doi.org/10.1093/burnst/tkaa022 |
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author | Shahin, Hady Elmasry, Moustafa Steinvall, Ingrid Söberg, Folke El-Serafi, Ahmed |
author_facet | Shahin, Hady Elmasry, Moustafa Steinvall, Ingrid Söberg, Folke El-Serafi, Ahmed |
author_sort | Shahin, Hady |
collection | PubMed |
description | Skin regeneration represents a promising line of management for patients with skin loss, including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties, vascularization can be markedly enhanced. The material effect, pore size and adsorption of certain proteins, as well as the application of appropriate growth factors, such as vascular endothelial growth factors, can have an additive effect. A selection of the most effective protocols is discussed in this review. |
format | Online Article Text |
id | pubmed-7396265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73962652020-08-05 Vascularization is the next challenge for skin tissue engineering as a solution for burn management Shahin, Hady Elmasry, Moustafa Steinvall, Ingrid Söberg, Folke El-Serafi, Ahmed Burns Trauma Review Skin regeneration represents a promising line of management for patients with skin loss, including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties, vascularization can be markedly enhanced. The material effect, pore size and adsorption of certain proteins, as well as the application of appropriate growth factors, such as vascular endothelial growth factors, can have an additive effect. A selection of the most effective protocols is discussed in this review. Oxford University Press 2020-08-03 /pmc/articles/PMC7396265/ /pubmed/32766342 http://dx.doi.org/10.1093/burnst/tkaa022 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Shahin, Hady Elmasry, Moustafa Steinvall, Ingrid Söberg, Folke El-Serafi, Ahmed Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title | Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title_full | Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title_fullStr | Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title_full_unstemmed | Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title_short | Vascularization is the next challenge for skin tissue engineering as a solution for burn management |
title_sort | vascularization is the next challenge for skin tissue engineering as a solution for burn management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396265/ https://www.ncbi.nlm.nih.gov/pubmed/32766342 http://dx.doi.org/10.1093/burnst/tkaa022 |
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