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Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed b...

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Autores principales: Cleynen, Isabelle, Engchuan, Worrawat, Hestand, Matthew S., Heung, Tracy, Holleman, Aaron M., Johnston, H. Richard, Monfeuga, Thomas, McDonald-McGinn, Donna M., Gur, Raquel E., Morrow, Bernice E., Swillen, Ann, Vorstman, Jacob A.S., Bearden, Carrie E., Chow, Eva W. C., van den Bree, Marianne, Emanuel, Beverly S., Vermeesch, Joris R., Warren, Stephen T., Owen, Michael J., Chopra, Pankaj, Cutler, David J., Duncan, Richard, Kotlar, Alex V., Mulle, Jennifer G., Voss, Anna J., Zwick, Michael E., Diacou, Alexander, Golden, Aaron, Guo, Tingwei, Lin, Jhih-Rong, Wang, Tao, Zhang, Zhengdong, Zhao, Yingjie, Marshall, Christian, Merico, Daniele, Jin, Andrea, Lilley, Brenna, Salmons, Harold I., Tran, Oanh, Holmans, Peter, Pardinas, Antonio, Walters, James T.R., Demaerel, Wolfram, Boot, Erik, Butcher, Nancy J., Costain, Gregory A., Lowther, Chelsea, Evers, Rens, van Amelsvoort, Therese A.M.J, van Duin, Esther, Vingerhoets, Claudia, Breckpot, Jeroen, Devriendt, Koen, Vergaelen, Elfi, Vogels, Annick, Crowley, T. Blaine, McGinn, Daniel E., Moss, Edward M., Sharkus, Robert J., Unolt, Marta, Zackai, Elaine H., Calkins, Monica E., Gallagher, Robert S., Gur, Ruben C., Tang, Sunny X., Fritsch, Rosemarie, Ornstein, Claudia, Repetto, Gabriela M., Breetvelt, Elemi, Duijff, Sasja N., Fiksinski, Ania, Moss, Hayley, Niarchou, Maria, Murphy, Kieran C., Prasad, Sarah E., Daly, Eileen M., Gudbrandsen, Maria, Murphy, Clodagh M., Murphy, Declan G., Buzzanca, Antonio, Di Fabio, Fabio, Digilio, Maria C., Pontillo, Maria, Marino, Bruno, Vicari, Stefano, Coleman, Karlene, Cubells, Joseph F., Ousley, Opal Y., Carmel, Miri, Gothelf, Doron, Mekori-Domachevsky, Ehud, Michaelovsky, Elena, Weinberger, Ronnie, Weizman, Abraham, Kushan, Leila, Jalbrzikowski, Maria, Armando, Marco, Eliez, Stéphan, Sandini, Corrado, Schneider, Maude, Béna, Frédérique Sloan, Antshel, Kevin M., Fremont, Wanda, Kates, Wendy R., Belzeaux, Raoul, Busa, Tiffany, Philip, Nicole, Campbell, Linda E., McCabe, Kathryn L., Hooper, Stephen R., Schoch, Kelly, Shashi, Vandana, Simon, Tony J., Tassone, Flora, Arango, Celso, Fraguas, David, García-Miñaúr, Sixto, Morey-Canyelles, Jaume, Rosell, Jordi, Suñer, Damià H., Raventos-Simic, Jasna, Epstein, Michael P., Williams, Nigel M., Bassett, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396297/
https://www.ncbi.nlm.nih.gov/pubmed/32015465
http://dx.doi.org/10.1038/s41380-020-0654-3
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author Cleynen, Isabelle
Engchuan, Worrawat
Hestand, Matthew S.
Heung, Tracy
Holleman, Aaron M.
Johnston, H. Richard
Monfeuga, Thomas
McDonald-McGinn, Donna M.
Gur, Raquel E.
Morrow, Bernice E.
Swillen, Ann
Vorstman, Jacob A.S.
Bearden, Carrie E.
Chow, Eva W. C.
van den Bree, Marianne
Emanuel, Beverly S.
Vermeesch, Joris R.
Warren, Stephen T.
Owen, Michael J.
Chopra, Pankaj
Cutler, David J.
Duncan, Richard
Kotlar, Alex V.
Mulle, Jennifer G.
Voss, Anna J.
Zwick, Michael E.
Diacou, Alexander
Golden, Aaron
Guo, Tingwei
Lin, Jhih-Rong
Wang, Tao
Zhang, Zhengdong
Zhao, Yingjie
Marshall, Christian
Merico, Daniele
Jin, Andrea
Lilley, Brenna
Salmons, Harold I.
Tran, Oanh
Holmans, Peter
Pardinas, Antonio
Walters, James T.R.
Demaerel, Wolfram
Boot, Erik
Butcher, Nancy J.
Costain, Gregory A.
Lowther, Chelsea
Evers, Rens
van Amelsvoort, Therese A.M.J
van Duin, Esther
Vingerhoets, Claudia
Breckpot, Jeroen
Devriendt, Koen
Vergaelen, Elfi
Vogels, Annick
Crowley, T. Blaine
McGinn, Daniel E.
Moss, Edward M.
Sharkus, Robert J.
Unolt, Marta
Zackai, Elaine H.
Calkins, Monica E.
Gallagher, Robert S.
Gur, Ruben C.
Tang, Sunny X.
Fritsch, Rosemarie
Ornstein, Claudia
Repetto, Gabriela M.
Breetvelt, Elemi
Duijff, Sasja N.
Fiksinski, Ania
Moss, Hayley
Niarchou, Maria
Murphy, Kieran C.
Prasad, Sarah E.
Daly, Eileen M.
Gudbrandsen, Maria
Murphy, Clodagh M.
Murphy, Declan G.
Buzzanca, Antonio
Di Fabio, Fabio
Digilio, Maria C.
Pontillo, Maria
Marino, Bruno
Vicari, Stefano
Coleman, Karlene
Cubells, Joseph F.
Ousley, Opal Y.
Carmel, Miri
Gothelf, Doron
Mekori-Domachevsky, Ehud
Michaelovsky, Elena
Weinberger, Ronnie
Weizman, Abraham
Kushan, Leila
Jalbrzikowski, Maria
Armando, Marco
Eliez, Stéphan
Sandini, Corrado
Schneider, Maude
Béna, Frédérique Sloan
Antshel, Kevin M.
Fremont, Wanda
Kates, Wendy R.
Belzeaux, Raoul
Busa, Tiffany
Philip, Nicole
Campbell, Linda E.
McCabe, Kathryn L.
Hooper, Stephen R.
Schoch, Kelly
Shashi, Vandana
Simon, Tony J.
Tassone, Flora
Arango, Celso
Fraguas, David
García-Miñaúr, Sixto
Morey-Canyelles, Jaume
Rosell, Jordi
Suñer, Damià H.
Raventos-Simic, Jasna
Epstein, Michael P.
Williams, Nigel M.
Bassett, Anne S.
author_facet Cleynen, Isabelle
Engchuan, Worrawat
Hestand, Matthew S.
Heung, Tracy
Holleman, Aaron M.
Johnston, H. Richard
Monfeuga, Thomas
McDonald-McGinn, Donna M.
Gur, Raquel E.
Morrow, Bernice E.
Swillen, Ann
Vorstman, Jacob A.S.
Bearden, Carrie E.
Chow, Eva W. C.
van den Bree, Marianne
Emanuel, Beverly S.
Vermeesch, Joris R.
Warren, Stephen T.
Owen, Michael J.
Chopra, Pankaj
Cutler, David J.
Duncan, Richard
Kotlar, Alex V.
Mulle, Jennifer G.
Voss, Anna J.
Zwick, Michael E.
Diacou, Alexander
Golden, Aaron
Guo, Tingwei
Lin, Jhih-Rong
Wang, Tao
Zhang, Zhengdong
Zhao, Yingjie
Marshall, Christian
Merico, Daniele
Jin, Andrea
Lilley, Brenna
Salmons, Harold I.
Tran, Oanh
Holmans, Peter
Pardinas, Antonio
Walters, James T.R.
Demaerel, Wolfram
Boot, Erik
Butcher, Nancy J.
Costain, Gregory A.
Lowther, Chelsea
Evers, Rens
van Amelsvoort, Therese A.M.J
van Duin, Esther
Vingerhoets, Claudia
Breckpot, Jeroen
Devriendt, Koen
Vergaelen, Elfi
Vogels, Annick
Crowley, T. Blaine
McGinn, Daniel E.
Moss, Edward M.
Sharkus, Robert J.
Unolt, Marta
Zackai, Elaine H.
Calkins, Monica E.
Gallagher, Robert S.
Gur, Ruben C.
Tang, Sunny X.
Fritsch, Rosemarie
Ornstein, Claudia
Repetto, Gabriela M.
Breetvelt, Elemi
Duijff, Sasja N.
Fiksinski, Ania
Moss, Hayley
Niarchou, Maria
Murphy, Kieran C.
Prasad, Sarah E.
Daly, Eileen M.
Gudbrandsen, Maria
Murphy, Clodagh M.
Murphy, Declan G.
Buzzanca, Antonio
Di Fabio, Fabio
Digilio, Maria C.
Pontillo, Maria
Marino, Bruno
Vicari, Stefano
Coleman, Karlene
Cubells, Joseph F.
Ousley, Opal Y.
Carmel, Miri
Gothelf, Doron
Mekori-Domachevsky, Ehud
Michaelovsky, Elena
Weinberger, Ronnie
Weizman, Abraham
Kushan, Leila
Jalbrzikowski, Maria
Armando, Marco
Eliez, Stéphan
Sandini, Corrado
Schneider, Maude
Béna, Frédérique Sloan
Antshel, Kevin M.
Fremont, Wanda
Kates, Wendy R.
Belzeaux, Raoul
Busa, Tiffany
Philip, Nicole
Campbell, Linda E.
McCabe, Kathryn L.
Hooper, Stephen R.
Schoch, Kelly
Shashi, Vandana
Simon, Tony J.
Tassone, Flora
Arango, Celso
Fraguas, David
García-Miñaúr, Sixto
Morey-Canyelles, Jaume
Rosell, Jordi
Suñer, Damià H.
Raventos-Simic, Jasna
Epstein, Michael P.
Williams, Nigel M.
Bassett, Anne S.
author_sort Cleynen, Isabelle
collection PubMed
description Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n=35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (p(adj)=6.73×10(−6)). Novel reciprocal case-control comparisons between the 22q11.2DS and population-based cohorts showed that polygenic risk score was significantly greater in individuals with psychotic illness, regardless of the presence of the 22q11.2 deletion. Within the 22q11.2DS cohort, results of gene-set analyses showed some support for rare variants affecting synaptic genes. No common or rare variants within the 22q11.2 deletion region were significantly associated with schizophrenia. These findings suggest that in addition to conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present.
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spelling pubmed-73962972021-08-03 Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion Cleynen, Isabelle Engchuan, Worrawat Hestand, Matthew S. Heung, Tracy Holleman, Aaron M. Johnston, H. Richard Monfeuga, Thomas McDonald-McGinn, Donna M. Gur, Raquel E. Morrow, Bernice E. Swillen, Ann Vorstman, Jacob A.S. Bearden, Carrie E. Chow, Eva W. C. van den Bree, Marianne Emanuel, Beverly S. Vermeesch, Joris R. Warren, Stephen T. Owen, Michael J. Chopra, Pankaj Cutler, David J. Duncan, Richard Kotlar, Alex V. Mulle, Jennifer G. Voss, Anna J. Zwick, Michael E. Diacou, Alexander Golden, Aaron Guo, Tingwei Lin, Jhih-Rong Wang, Tao Zhang, Zhengdong Zhao, Yingjie Marshall, Christian Merico, Daniele Jin, Andrea Lilley, Brenna Salmons, Harold I. Tran, Oanh Holmans, Peter Pardinas, Antonio Walters, James T.R. Demaerel, Wolfram Boot, Erik Butcher, Nancy J. Costain, Gregory A. Lowther, Chelsea Evers, Rens van Amelsvoort, Therese A.M.J van Duin, Esther Vingerhoets, Claudia Breckpot, Jeroen Devriendt, Koen Vergaelen, Elfi Vogels, Annick Crowley, T. Blaine McGinn, Daniel E. Moss, Edward M. Sharkus, Robert J. Unolt, Marta Zackai, Elaine H. Calkins, Monica E. Gallagher, Robert S. Gur, Ruben C. Tang, Sunny X. Fritsch, Rosemarie Ornstein, Claudia Repetto, Gabriela M. Breetvelt, Elemi Duijff, Sasja N. Fiksinski, Ania Moss, Hayley Niarchou, Maria Murphy, Kieran C. Prasad, Sarah E. Daly, Eileen M. Gudbrandsen, Maria Murphy, Clodagh M. Murphy, Declan G. Buzzanca, Antonio Di Fabio, Fabio Digilio, Maria C. Pontillo, Maria Marino, Bruno Vicari, Stefano Coleman, Karlene Cubells, Joseph F. Ousley, Opal Y. Carmel, Miri Gothelf, Doron Mekori-Domachevsky, Ehud Michaelovsky, Elena Weinberger, Ronnie Weizman, Abraham Kushan, Leila Jalbrzikowski, Maria Armando, Marco Eliez, Stéphan Sandini, Corrado Schneider, Maude Béna, Frédérique Sloan Antshel, Kevin M. Fremont, Wanda Kates, Wendy R. Belzeaux, Raoul Busa, Tiffany Philip, Nicole Campbell, Linda E. McCabe, Kathryn L. Hooper, Stephen R. Schoch, Kelly Shashi, Vandana Simon, Tony J. Tassone, Flora Arango, Celso Fraguas, David García-Miñaúr, Sixto Morey-Canyelles, Jaume Rosell, Jordi Suñer, Damià H. Raventos-Simic, Jasna Epstein, Michael P. Williams, Nigel M. Bassett, Anne S. Mol Psychiatry Article Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n=35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (p(adj)=6.73×10(−6)). Novel reciprocal case-control comparisons between the 22q11.2DS and population-based cohorts showed that polygenic risk score was significantly greater in individuals with psychotic illness, regardless of the presence of the 22q11.2 deletion. Within the 22q11.2DS cohort, results of gene-set analyses showed some support for rare variants affecting synaptic genes. No common or rare variants within the 22q11.2 deletion region were significantly associated with schizophrenia. These findings suggest that in addition to conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present. 2020-02-03 2021-08 /pmc/articles/PMC7396297/ /pubmed/32015465 http://dx.doi.org/10.1038/s41380-020-0654-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Cleynen, Isabelle
Engchuan, Worrawat
Hestand, Matthew S.
Heung, Tracy
Holleman, Aaron M.
Johnston, H. Richard
Monfeuga, Thomas
McDonald-McGinn, Donna M.
Gur, Raquel E.
Morrow, Bernice E.
Swillen, Ann
Vorstman, Jacob A.S.
Bearden, Carrie E.
Chow, Eva W. C.
van den Bree, Marianne
Emanuel, Beverly S.
Vermeesch, Joris R.
Warren, Stephen T.
Owen, Michael J.
Chopra, Pankaj
Cutler, David J.
Duncan, Richard
Kotlar, Alex V.
Mulle, Jennifer G.
Voss, Anna J.
Zwick, Michael E.
Diacou, Alexander
Golden, Aaron
Guo, Tingwei
Lin, Jhih-Rong
Wang, Tao
Zhang, Zhengdong
Zhao, Yingjie
Marshall, Christian
Merico, Daniele
Jin, Andrea
Lilley, Brenna
Salmons, Harold I.
Tran, Oanh
Holmans, Peter
Pardinas, Antonio
Walters, James T.R.
Demaerel, Wolfram
Boot, Erik
Butcher, Nancy J.
Costain, Gregory A.
Lowther, Chelsea
Evers, Rens
van Amelsvoort, Therese A.M.J
van Duin, Esther
Vingerhoets, Claudia
Breckpot, Jeroen
Devriendt, Koen
Vergaelen, Elfi
Vogels, Annick
Crowley, T. Blaine
McGinn, Daniel E.
Moss, Edward M.
Sharkus, Robert J.
Unolt, Marta
Zackai, Elaine H.
Calkins, Monica E.
Gallagher, Robert S.
Gur, Ruben C.
Tang, Sunny X.
Fritsch, Rosemarie
Ornstein, Claudia
Repetto, Gabriela M.
Breetvelt, Elemi
Duijff, Sasja N.
Fiksinski, Ania
Moss, Hayley
Niarchou, Maria
Murphy, Kieran C.
Prasad, Sarah E.
Daly, Eileen M.
Gudbrandsen, Maria
Murphy, Clodagh M.
Murphy, Declan G.
Buzzanca, Antonio
Di Fabio, Fabio
Digilio, Maria C.
Pontillo, Maria
Marino, Bruno
Vicari, Stefano
Coleman, Karlene
Cubells, Joseph F.
Ousley, Opal Y.
Carmel, Miri
Gothelf, Doron
Mekori-Domachevsky, Ehud
Michaelovsky, Elena
Weinberger, Ronnie
Weizman, Abraham
Kushan, Leila
Jalbrzikowski, Maria
Armando, Marco
Eliez, Stéphan
Sandini, Corrado
Schneider, Maude
Béna, Frédérique Sloan
Antshel, Kevin M.
Fremont, Wanda
Kates, Wendy R.
Belzeaux, Raoul
Busa, Tiffany
Philip, Nicole
Campbell, Linda E.
McCabe, Kathryn L.
Hooper, Stephen R.
Schoch, Kelly
Shashi, Vandana
Simon, Tony J.
Tassone, Flora
Arango, Celso
Fraguas, David
García-Miñaúr, Sixto
Morey-Canyelles, Jaume
Rosell, Jordi
Suñer, Damià H.
Raventos-Simic, Jasna
Epstein, Michael P.
Williams, Nigel M.
Bassett, Anne S.
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title_full Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title_fullStr Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title_full_unstemmed Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title_short Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
title_sort genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396297/
https://www.ncbi.nlm.nih.gov/pubmed/32015465
http://dx.doi.org/10.1038/s41380-020-0654-3
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AT mosshayley geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT niarchoumaria geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT murphykieranc geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT prasadsarahe geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT dalyeileenm geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT gudbrandsenmaria geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT murphyclodaghm geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT murphydeclang geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT buzzancaantonio geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT difabiofabio geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT digiliomariac geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT pontillomaria geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT marinobruno geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT vicaristefano geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT colemankarlene geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT cubellsjosephf geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT ousleyopaly geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT carmelmiri geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT gothelfdoron geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT mekoridomachevskyehud geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT michaelovskyelena geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT weinbergerronnie geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT weizmanabraham geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT kushanleila geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT jalbrzikowskimaria geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT armandomarco geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT eliezstephan geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT sandinicorrado geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT schneidermaude geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT benafrederiquesloan geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT antshelkevinm geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT fremontwanda geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT kateswendyr geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT belzeauxraoul geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT busatiffany geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT philipnicole geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT campbelllindae geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT mccabekathrynl geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT hooperstephenr geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT schochkelly geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT shashivandana geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT simontonyj geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT tassoneflora geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT arangocelso geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT fraguasdavid geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT garciaminaursixto geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT moreycanyellesjaume geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT roselljordi geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT sunerdamiah geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT raventossimicjasna geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT epsteinmichaelp geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT williamsnigelm geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion
AT bassettannes geneticcontributorstoriskofschizophreniainthepresenceofa22q112deletion