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Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience
BACKGROUND: Venous thromboembolism (VTE) is a common postoperative complication. Previous studies have shown that the VTE incidence after major thoracic surgery is high. However, there have been no exclusive data after thymectomy thus far. To investigate the incidence of postoperative VTE, we conduc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396359/ https://www.ncbi.nlm.nih.gov/pubmed/32558357 http://dx.doi.org/10.1111/1759-7714.13543 |
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author | Yang, Xingguo Yu, Lei Yu, Tao Li, Fei Zhang, Yunfeng Yu, Zhen Zhang, Baoxun Ke, Ji Li, Hui |
author_facet | Yang, Xingguo Yu, Lei Yu, Tao Li, Fei Zhang, Yunfeng Yu, Zhen Zhang, Baoxun Ke, Ji Li, Hui |
author_sort | Yang, Xingguo |
collection | PubMed |
description | BACKGROUND: Venous thromboembolism (VTE) is a common postoperative complication. Previous studies have shown that the VTE incidence after major thoracic surgery is high. However, there have been no exclusive data after thymectomy thus far. To investigate the incidence of postoperative VTE, we conducted a single‐center, prospective cohort study. METHODS: Patients who underwent thymectomy between December 2017 and January 2020 were enrolled. None of the patients received any prophylaxis perioperatively. Subjects were risk stratified into groups of low risk (0–4), moderate risk (5–8), and high risk (≥9). Occurrence of VTE events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), were identified by imaging. RESULTS: There were 192 patients who underwent thymectomy enrolled into the study. The overall VTE incidence was 8.9%. All the patients were diagnosed with DVT, and none were diagnosed with PE. The VTE incidence was 4.6% in patients with benign thymic diseases and 14.5% with malignant diseases. The VTE incidence was 4.7% in patients undergoing thoracoscopic surgery and 22.7% undergoing median sternotomy. The VTE incidence increased with Caprini score. Scores in the low, moderate, and high risk groups were associated with a VTE incidence of 0%, 10.3% and 37.5%, respectively. In patients with thymic malignancy, the VTE incidence in the moderate and high risk groups were 8.8% and 31.8%, respectively. CONCLUSIONS: VTE occurred frequently in patients after thymectomy without VTE prophylaxis. The median sternotomy procedure and malignant tumor may be the major risk factors for the development of VTE. Aggressive VTE screening/treatment protocols should be implemented in patents after thymectomy. |
format | Online Article Text |
id | pubmed-7396359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73963592020-08-06 Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience Yang, Xingguo Yu, Lei Yu, Tao Li, Fei Zhang, Yunfeng Yu, Zhen Zhang, Baoxun Ke, Ji Li, Hui Thorac Cancer Original Articles BACKGROUND: Venous thromboembolism (VTE) is a common postoperative complication. Previous studies have shown that the VTE incidence after major thoracic surgery is high. However, there have been no exclusive data after thymectomy thus far. To investigate the incidence of postoperative VTE, we conducted a single‐center, prospective cohort study. METHODS: Patients who underwent thymectomy between December 2017 and January 2020 were enrolled. None of the patients received any prophylaxis perioperatively. Subjects were risk stratified into groups of low risk (0–4), moderate risk (5–8), and high risk (≥9). Occurrence of VTE events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), were identified by imaging. RESULTS: There were 192 patients who underwent thymectomy enrolled into the study. The overall VTE incidence was 8.9%. All the patients were diagnosed with DVT, and none were diagnosed with PE. The VTE incidence was 4.6% in patients with benign thymic diseases and 14.5% with malignant diseases. The VTE incidence was 4.7% in patients undergoing thoracoscopic surgery and 22.7% undergoing median sternotomy. The VTE incidence increased with Caprini score. Scores in the low, moderate, and high risk groups were associated with a VTE incidence of 0%, 10.3% and 37.5%, respectively. In patients with thymic malignancy, the VTE incidence in the moderate and high risk groups were 8.8% and 31.8%, respectively. CONCLUSIONS: VTE occurred frequently in patients after thymectomy without VTE prophylaxis. The median sternotomy procedure and malignant tumor may be the major risk factors for the development of VTE. Aggressive VTE screening/treatment protocols should be implemented in patents after thymectomy. John Wiley & Sons Australia, Ltd 2020-06-18 2020-08 /pmc/articles/PMC7396359/ /pubmed/32558357 http://dx.doi.org/10.1111/1759-7714.13543 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yang, Xingguo Yu, Lei Yu, Tao Li, Fei Zhang, Yunfeng Yu, Zhen Zhang, Baoxun Ke, Ji Li, Hui Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title | Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title_full | Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title_fullStr | Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title_full_unstemmed | Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title_short | Venous thromboembolism after adult thymus or thymic tumor resection: A single‐center experience |
title_sort | venous thromboembolism after adult thymus or thymic tumor resection: a single‐center experience |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396359/ https://www.ncbi.nlm.nih.gov/pubmed/32558357 http://dx.doi.org/10.1111/1759-7714.13543 |
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