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Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers
PURPOSE: This study evaluates the quantitative effect of improved MR-based attenuation correction (AC), including bone segmentation and the HUGE method for truncation correction in PET/MR whole-body hybrid imaging specifically of oncologic patients with bone metastasis and using various radiotracers...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396397/ https://www.ncbi.nlm.nih.gov/pubmed/32125487 http://dx.doi.org/10.1007/s00259-020-04738-6 |
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author | Grafe, Hong Lindemann, Maike E. Ruhlmann, Verena Oehmigen, Mark Hirmas, Nader Umutlu, Lale Herrmann, Ken Quick, Harald H. |
author_facet | Grafe, Hong Lindemann, Maike E. Ruhlmann, Verena Oehmigen, Mark Hirmas, Nader Umutlu, Lale Herrmann, Ken Quick, Harald H. |
author_sort | Grafe, Hong |
collection | PubMed |
description | PURPOSE: This study evaluates the quantitative effect of improved MR-based attenuation correction (AC), including bone segmentation and the HUGE method for truncation correction in PET/MR whole-body hybrid imaging specifically of oncologic patients with bone metastasis and using various radiotracers. METHODS: Twenty-three patients that underwent altogether 28 whole-body PET/MR examinations with findings of bone metastasis were included in this study. Different radiotracers ((18)F-FDG, (68)Ga-PSMA, (68)Ga-DOTATOC, (124)I–MIBG) were injected according to appropriate clinical indications. Each of the 28 whole-body PET datasets was reconstructed three times using AC with (1) standard four-compartment μ-maps (background air, lung, muscle, and soft tissue), (2) five-compartment μ-maps (adding bone), and (3) six-compartment μ-maps (adding bone and HUGE truncation correction). The SUV(max) of each detected bone lesion was measured in each reconstruction to evaluate the quantitative impact of improved MR-based AC. Relative difference images between four- and six-compartment μ-maps were calculated. MR-based HUGE truncation correction was compared with the PET-based MLAA truncation correction method in all patients. RESULTS: Overall, 69 bone lesions were detected and evaluated. The mean increase in relative difference over all 69 lesions in SUV(max) was 5.4 ± 6.4% when comparing the improved six-compartment AC with the standard four-compartment AC. Maximal relative difference of 28.4% was measured in one lesion. Truncation correction with HUGE worked robust and resulted in realistic body contouring in all 28 exams and for all 4 different radiotracers. Truncation correction with MLAA revealed overestimations of arm tissue volume in all PET/MR exams with (18)F-FDG radiotracer and failed in all other exams with radiotracers (68)Ga-PSMA, (68)Ga-DOTATOC, and (124)I- MIBG due to limitations in body contour detection. CONCLUSION: Improved MR-based AC, including bone segmentation and HUGE truncation correction in whole-body PET/MR on patients with bone lesions and using various radiotracers, is important to ensure best possible diagnostic image quality and accurate PET quantification. The HUGE method for truncation correction based on MR worked robust and results in realistic body contouring, independent of the radiotracers used. |
format | Online Article Text |
id | pubmed-7396397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73963972020-08-13 Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers Grafe, Hong Lindemann, Maike E. Ruhlmann, Verena Oehmigen, Mark Hirmas, Nader Umutlu, Lale Herrmann, Ken Quick, Harald H. Eur J Nucl Med Mol Imaging Original Article PURPOSE: This study evaluates the quantitative effect of improved MR-based attenuation correction (AC), including bone segmentation and the HUGE method for truncation correction in PET/MR whole-body hybrid imaging specifically of oncologic patients with bone metastasis and using various radiotracers. METHODS: Twenty-three patients that underwent altogether 28 whole-body PET/MR examinations with findings of bone metastasis were included in this study. Different radiotracers ((18)F-FDG, (68)Ga-PSMA, (68)Ga-DOTATOC, (124)I–MIBG) were injected according to appropriate clinical indications. Each of the 28 whole-body PET datasets was reconstructed three times using AC with (1) standard four-compartment μ-maps (background air, lung, muscle, and soft tissue), (2) five-compartment μ-maps (adding bone), and (3) six-compartment μ-maps (adding bone and HUGE truncation correction). The SUV(max) of each detected bone lesion was measured in each reconstruction to evaluate the quantitative impact of improved MR-based AC. Relative difference images between four- and six-compartment μ-maps were calculated. MR-based HUGE truncation correction was compared with the PET-based MLAA truncation correction method in all patients. RESULTS: Overall, 69 bone lesions were detected and evaluated. The mean increase in relative difference over all 69 lesions in SUV(max) was 5.4 ± 6.4% when comparing the improved six-compartment AC with the standard four-compartment AC. Maximal relative difference of 28.4% was measured in one lesion. Truncation correction with HUGE worked robust and resulted in realistic body contouring in all 28 exams and for all 4 different radiotracers. Truncation correction with MLAA revealed overestimations of arm tissue volume in all PET/MR exams with (18)F-FDG radiotracer and failed in all other exams with radiotracers (68)Ga-PSMA, (68)Ga-DOTATOC, and (124)I- MIBG due to limitations in body contour detection. CONCLUSION: Improved MR-based AC, including bone segmentation and HUGE truncation correction in whole-body PET/MR on patients with bone lesions and using various radiotracers, is important to ensure best possible diagnostic image quality and accurate PET quantification. The HUGE method for truncation correction based on MR worked robust and results in realistic body contouring, independent of the radiotracers used. Springer Berlin Heidelberg 2020-03-03 2020 /pmc/articles/PMC7396397/ /pubmed/32125487 http://dx.doi.org/10.1007/s00259-020-04738-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Grafe, Hong Lindemann, Maike E. Ruhlmann, Verena Oehmigen, Mark Hirmas, Nader Umutlu, Lale Herrmann, Ken Quick, Harald H. Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title | Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title_full | Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title_fullStr | Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title_full_unstemmed | Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title_short | Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers |
title_sort | evaluation of improved attenuation correction in whole-body pet/mr on patients with bone metastasis using various radiotracers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396397/ https://www.ncbi.nlm.nih.gov/pubmed/32125487 http://dx.doi.org/10.1007/s00259-020-04738-6 |
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