In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response

In a syngeneic murine melanoma (MEL) model, we recently reported an in situ vaccination response to combined radiation (RT) and intra-tumoral (IT) injection of anti-GD2 hu14. 18-IL2 immunocytokine (IC). This combined treatment resulted in 71% complete and durable regression of 5-week tumors, a tumor...

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Detalles Bibliográficos
Autores principales: Baniel, Claire C., Heinze, Clinton M., Hoefges, Anna, Sumiec, Elizabeth G., Hank, Jaquelyn A., Carlson, Peter M., Jin, Won Jong, Patel, Ravi B., Sriramaneni, Raghava N., Gillies, Stephen D., Erbe, Amy K., Schwarz, Ciara N., Pieper, Alexander A., Rakhmilevich, Alexander L., Sondel, Paul M., Morris, Zachary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396490/
https://www.ncbi.nlm.nih.gov/pubmed/32849544
http://dx.doi.org/10.3389/fimmu.2020.01610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396490/
https://www.ncbi.nlm.nih.gov/pubmed/32849544
http://dx.doi.org/10.3389/fimmu.2020.01610

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