Cargando…

Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice

Poor postoperative pain (POP) control increases perioperative morbidity, prolongs hospitalization days, and causes chronic pain. However, the specific mechanism(s) underlying POP is unclear and the identification of optimal perioperative treatment remains elusive. Akt and mammalian target of rapamyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Bing, Liu, Su-Su, Wei, Jin, Jiao, Zi-Yin, Mo, Cheng, Lv, Cheng-Mei, Huang, Ai-Lan, Chen, Qi-Bo, Ma, Li, Guan, Xue-Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396510/ https://www.ncbi.nlm.nih.gov/pubmed/32848550 http://dx.doi.org/10.3389/fnins.2020.00766

Ejemplares similares

Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice
por: Xu, Bing, et al.
Publicado: (2019)

Sciatic Nerve Block Combined with Flurbiprofen Inhibits Spinal Cord Inflammation and Improves Postoperative Pain in Rats with Plantar Incision
por: Li, Meihong, et al.
Publicado: (2023)

Longitudinal peripheral tissue RNA‐Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model
por: Goto, Taichi, et al.
Publicado: (2021)

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury
por: Walker, Chandler L., et al.
Publicado: (2012)

mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats
por: He, Wan-You, et al.
Publicado: (2019)

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia Induced by Tetrahydrobiopterin in Chronic Restraint Stress Rats
por: Huang, Ying, et al.
Publicado: (2021)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia
por: Lutz, Brianna Marie, et al.
Publicado: (2015)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway
por: Sun, Xin, et al.
Publicado: (2022)

Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
por: Zhou, Jingying, et al.
Publicado: (2018)

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway
por: Wang, Xichen, et al.
Publicado: (2022)

Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA-21-mediated PTEN/AKT/mTOR pathway
por: Sun, Tianyu, et al.
Publicado: (2021)

Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways
por: Roy, Gaurab, et al.
Publicado: (2019)

“mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury
por: Lin, Jingquan, et al.
Publicado: (2017)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway
por: Lyu, Xi, et al.
Publicado: (2019)

Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
por: Bai, Guang, et al.
Publicado: (2010)

Epigenetic regulation of spinal cord gene expression controls Opioid-Induced Hyperalgesia
por: Liang, De-Yong, et al.
Publicado: (2014)

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling
por: Cheng, Dong-dong, et al.
Publicado: (2018)

The PI3K/AKT/mTOR Signaling Pathway Is Overactivated in Primary Aldosteronism
por: Su, Hengchuan, et al.
Publicado: (2013)

CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma
por: Wang, Weiyuan, et al.
Publicado: (2014)

Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
por: Lv, Lijun, et al.
Publicado: (2023)

Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury
por: Wang, Xiaoping, et al.
Publicado: (2016)

Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response
por: Vargova, Ingrid, et al.
Publicado: (2021)

Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
por: Guo, Zhaoxin, et al.
Publicado: (2015)

Synergistic Effects of Combination Therapy with AKT and mTOR Inhibitors on Bladder Cancer Cells
por: Kim, Hyera, et al.
Publicado: (2020)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis
por: Zhao, Jia-Xing, et al.
Publicado: (2017)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2023)

Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia
por: Sluka, KA, et al.
Publicado: (2006)

Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators
por: Cheng, Yuan, et al.
Publicado: (2015)

GPR41 Regulates the Proliferation of BRECs via the PIK3-AKT-mTOR Pathway
por: Meng, Zitong, et al.
Publicado: (2023)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

Local analgesic effect of tramadol is mediated by opioid receptors in late postoperative pain after plantar incision in rats
por: de Oliveira Junior, José Oswaldo, et al.
Publicado: (2016)

RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway
por: Jiao, Yuheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1g8jmuknnd2jm9akjq5ott067a