Cargando…

Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (DAergic) neurons in the ventral brain. A disaccharide trehalose has demonstrated the potential to mitigate the DAergic loss in disease models for PD. However, trehalose is rapidly hy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Chih-Hsin, Wei, Pei-Cih, Chen, Chiung-Mei, Huang, Yu-Ting, Lin, Jia-Lan, Lo, Yen-Shi, Lin, Jia-Li, Lin, Chung-Yin, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396622/ https://www.ncbi.nlm.nih.gov/pubmed/32848705 http://dx.doi.org/10.3389/fnagi.2020.00226

Ejemplares similares

Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability
por: Chen, Chiung Mei, et al.
Publicado: (2020)

Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson’s Disease Targeting Neuroinflammation
por: Chen, Chiung-Mei, et al.
Publicado: (2021)

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models
por: Wei, Pei-Cih, et al.
Publicado: (2019)

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation
por: Chiu, Ya-Jen, et al.
Publicado: (2020)

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease
por: Chiu, Ya-Jen, et al.
Publicado: (2023)

Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity
por: Wei, Pei-Cih, et al.
Publicado: (2022)

Indium-mediated C-allylation of melibiose
por: Denner, Christian, et al.
Publicado: (2019)

Rare VPS35 A320V Variant in Taiwanese Parkinson’s Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology
por: Wu, Yih-Ru, et al.
Publicado: (2020)

Biomarker of Neuroinflammation in Parkinson’s Disease
por: Liu, Tsai-Wei, et al.
Publicado: (2022)

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement
por: Chiu, Ya-Jen, et al.
Publicado: (2021)

STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan
por: Chang, Kuo-Hsuan, et al.
Publicado: (2015)

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2016)

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease
por: Chiang, Han-Lin, et al.
Publicado: (2020)

Assessment of the pharmacokinetics, removal rate of hemodialysis, and safety of lactulose in hemodialysis patients
por: Lin, Cheng-Jui, et al.
Publicado: (2016)

Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity
por: Yang, Pei-Ning, et al.
Publicado: (2023)

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population
por: Chang, Kuo-Hsuan, et al.
Publicado: (2013)

The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease
por: Schwenkgrub, Joanna, et al.
Publicado: (2017)

Structure-based mechanism for Na(+)/melibiose symport by MelB
por: Ethayathulla, Abdul S., et al.
Publicado: (2014)

Giant GAL gene clusters for the melibiose‐galactose pathway in Torulaspora
por: Venkatesh, Anjan, et al.
Publicado: (2020)

Complete cysteine-scanning mutagenesis of the Salmonella typhimurium melibiose permease
por: Markham, Kelsey J., et al.
Publicado: (2021)

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation
por: Chen, I-Cheng, et al.
Publicado: (2018)

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
por: Chang, Kuo-Hsuan, et al.
Publicado: (2013)

Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models
por: Lin, Te‐Hsien, et al.
Publicado: (2020)

Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
por: Ma, Chunmei, et al.
Publicado: (2023)

New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models
por: Chen, Chiung-Mei, et al.
Publicado: (2020)

Cooperative binding ensures the obligatory melibiose/Na(+) cotransport in MelB
por: Hariharan, Parameswaran, et al.
Publicado: (2021)

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation
por: Chang, Kuo-Hsuan, et al.
Publicado: (2018)

Design and application of a lactulose biosensor
por: Wu, Jieyuan, et al.
Publicado: (2017)

Using ΔK280 Tau(RD) Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy
por: Weng, Zheng-Kui, et al.
Publicado: (2023)

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
por: Yan, Aijuan, et al.
Publicado: (2019)

“Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson’s disease”
por: Rodríguez-Cruz, Alfredo, et al.
Publicado: (2019)

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models
por: Chen, Chiung-Mei, et al.
Publicado: (2019)

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3
por: Li, Dongsheng, et al.
Publicado: (2017)

Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons
por: Wu, Zhiyuan, et al.
Publicado: (2021)

METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum
por: Xie, Xiao-Li, et al.
Publicado: (2018)

FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease
por: Chen, Chiung-Mei, et al.
Publicado: (2014)

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease
por: Quan, Wei, et al.
Publicado: (2023)

Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA
por: Chen, I-Cheng, et al.
Publicado: (2013)

Chronic behavioral stress exaggerates motor deficit and neuroinflammation in the MPTP mouse model of Parkinson's disease
por: Lauretti, E, et al.
Publicado: (2016)

Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson’s Disease Models
por: Ham, Hyeon Joo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sldolm0fgt89v835jg6r934ics