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Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress

The bone marrow contains distinct cell types that work in coordination to generate blood and immune cells, and it is the primary residence of hematopoietic stem cells (HSCs) and more committed multipotent progenitors (MPPs). Even at homeostasis the bone marrow is a dynamic environment where billions...

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Autores principales: Seyfried, Allison N., Maloney, Jackson M., MacNamara, Katherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396643/
https://www.ncbi.nlm.nih.gov/pubmed/32849512
http://dx.doi.org/10.3389/fimmu.2020.01499
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author Seyfried, Allison N.
Maloney, Jackson M.
MacNamara, Katherine C.
author_facet Seyfried, Allison N.
Maloney, Jackson M.
MacNamara, Katherine C.
author_sort Seyfried, Allison N.
collection PubMed
description The bone marrow contains distinct cell types that work in coordination to generate blood and immune cells, and it is the primary residence of hematopoietic stem cells (HSCs) and more committed multipotent progenitors (MPPs). Even at homeostasis the bone marrow is a dynamic environment where billions of cells are generated daily to replenish short-lived immune cells and produce the blood factors and cells essential for hemostasis and oxygenation. In response to injury or infection, the marrow rapidly adapts to produce specific cell types that are in high demand revealing key insight to the inflammatory nature of “demand-adapted” hematopoiesis. Here we focus on the role that resident and monocyte-derived macrophages play in driving these hematopoietic programs and how macrophages impact HSCs and downstream MPPs. Macrophages are exquisite sensors of inflammation and possess the capacity to adapt to the environment, both promoting and restraining inflammation. Thus, macrophages hold great potential for manipulating hematopoietic output and as potential therapeutic targets in a variety of disease states where macrophage dysfunction contributes to or is necessary for disease. We highlight essential features of bone marrow macrophages and discuss open questions regarding macrophage function, their role in orchestrating demand-adapted hematopoiesis, and mechanisms whereby they regulate HSC function.
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spelling pubmed-73966432020-08-25 Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress Seyfried, Allison N. Maloney, Jackson M. MacNamara, Katherine C. Front Immunol Immunology The bone marrow contains distinct cell types that work in coordination to generate blood and immune cells, and it is the primary residence of hematopoietic stem cells (HSCs) and more committed multipotent progenitors (MPPs). Even at homeostasis the bone marrow is a dynamic environment where billions of cells are generated daily to replenish short-lived immune cells and produce the blood factors and cells essential for hemostasis and oxygenation. In response to injury or infection, the marrow rapidly adapts to produce specific cell types that are in high demand revealing key insight to the inflammatory nature of “demand-adapted” hematopoiesis. Here we focus on the role that resident and monocyte-derived macrophages play in driving these hematopoietic programs and how macrophages impact HSCs and downstream MPPs. Macrophages are exquisite sensors of inflammation and possess the capacity to adapt to the environment, both promoting and restraining inflammation. Thus, macrophages hold great potential for manipulating hematopoietic output and as potential therapeutic targets in a variety of disease states where macrophage dysfunction contributes to or is necessary for disease. We highlight essential features of bone marrow macrophages and discuss open questions regarding macrophage function, their role in orchestrating demand-adapted hematopoiesis, and mechanisms whereby they regulate HSC function. Frontiers Media S.A. 2020-07-23 /pmc/articles/PMC7396643/ /pubmed/32849512 http://dx.doi.org/10.3389/fimmu.2020.01499 Text en Copyright © 2020 Seyfried, Maloney and MacNamara. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Seyfried, Allison N.
Maloney, Jackson M.
MacNamara, Katherine C.
Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title_full Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title_fullStr Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title_full_unstemmed Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title_short Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
title_sort macrophages orchestrate hematopoietic programs and regulate hsc function during inflammatory stress
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396643/
https://www.ncbi.nlm.nih.gov/pubmed/32849512
http://dx.doi.org/10.3389/fimmu.2020.01499
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