CCR5 deficiency impairs CD4(+) T‐cell memory responses and antigenic sensitivity through increased ceramide synthesis

CCR5 is not only a coreceptor for HIV‐1 infection in CD4(+) T cells, but also contributes to their functional fitness. Here, we show that by limiting transcription of specific ceramide synthases, CCR5 signaling reduces ceramide levels and thereby increases T‐cell antigen receptor (TCR) nanoclusterin...

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Detalles Bibliográficos
Autores principales: Martín‐Leal, Ana, Blanco, Raquel, Casas, Josefina, Sáez, María E, Rodríguez‐Bovolenta, Elena, de Rojas, Itziar, Drechsler, Carina, Real, Luis Miguel, Fabrias, Gemma, Ruíz, Agustín, Castro, Mario, Schamel, Wolfgang WA, Alarcón, Balbino, van Santen, Hisse M, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396835/
https://www.ncbi.nlm.nih.gov/pubmed/32525588
http://dx.doi.org/10.15252/embj.2020104749

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