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Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review
Erectile dysfunction (ED) is a prevalent condition, especially in men over 40 years old, characterized by the inability to obtain and/or maintain penile erection sufficient for satisfactory sexual intercourse. Several psychological and/or organic factors are involved in the etiopathogenesis of ED. I...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396897/ https://www.ncbi.nlm.nih.gov/pubmed/32848741 http://dx.doi.org/10.3389/fphar.2020.01120 |
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author | Diniz, Anderson Fellyp Avelino Ferreira, Rafael Carlos de Souza, Iara Leão Luna da Silva, Bagnólia Araújo |
author_facet | Diniz, Anderson Fellyp Avelino Ferreira, Rafael Carlos de Souza, Iara Leão Luna da Silva, Bagnólia Araújo |
author_sort | Diniz, Anderson Fellyp Avelino |
collection | PubMed |
description | Erectile dysfunction (ED) is a prevalent condition, especially in men over 40 years old, characterized by the inability to obtain and/or maintain penile erection sufficient for satisfactory sexual intercourse. Several psychological and/or organic factors are involved in the etiopathogenesis of ED. In this context, we gathered evidence of the involvement of Large-conductance, Ca(2+)-activated K(+) channels (BK(Ca)), Small-conductance, Ca(2+)-activated K(+) channels (SK(Ca)), KCNQ-encoded voltage-dependent K(+) channels (K(V)7), Transient Receptor Potential channels (TRP), and Calcium-activated Chloride channels (CaCC) dysfunctions on ED. In addition, the use of modulating agents of these channels are involved in relaxation of the cavernous smooth muscle cell and, consequent penile erection, suggesting that these channels are promising therapeutic targets for the treatment of erectile dysfunction. |
format | Online Article Text |
id | pubmed-7396897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73968972020-08-25 Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review Diniz, Anderson Fellyp Avelino Ferreira, Rafael Carlos de Souza, Iara Leão Luna da Silva, Bagnólia Araújo Front Pharmacol Pharmacology Erectile dysfunction (ED) is a prevalent condition, especially in men over 40 years old, characterized by the inability to obtain and/or maintain penile erection sufficient for satisfactory sexual intercourse. Several psychological and/or organic factors are involved in the etiopathogenesis of ED. In this context, we gathered evidence of the involvement of Large-conductance, Ca(2+)-activated K(+) channels (BK(Ca)), Small-conductance, Ca(2+)-activated K(+) channels (SK(Ca)), KCNQ-encoded voltage-dependent K(+) channels (K(V)7), Transient Receptor Potential channels (TRP), and Calcium-activated Chloride channels (CaCC) dysfunctions on ED. In addition, the use of modulating agents of these channels are involved in relaxation of the cavernous smooth muscle cell and, consequent penile erection, suggesting that these channels are promising therapeutic targets for the treatment of erectile dysfunction. Frontiers Media S.A. 2020-07-24 /pmc/articles/PMC7396897/ /pubmed/32848741 http://dx.doi.org/10.3389/fphar.2020.01120 Text en Copyright © 2020 Diniz, Ferreira, de Souza and da Silva http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Diniz, Anderson Fellyp Avelino Ferreira, Rafael Carlos de Souza, Iara Leão Luna da Silva, Bagnólia Araújo Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title | Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title_full | Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title_fullStr | Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title_full_unstemmed | Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title_short | Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review |
title_sort | ionic channels as potential therapeutic targets for erectile dysfunction: a review |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396897/ https://www.ncbi.nlm.nih.gov/pubmed/32848741 http://dx.doi.org/10.3389/fphar.2020.01120 |
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