Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase

Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide-dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, the PDK1 feedback mechanism remains elusive....

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Detalles Bibliográficos
Autores principales: Kim, Kidae, Park, Sung Goo, Park, Byoung Chul, Kim, Jeong-Hoon, Kim, Sunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396916/
https://www.ncbi.nlm.nih.gov/pubmed/32317083
http://dx.doi.org/10.5483/BMBRep.2020.53.7.299

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