Cargando…
Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis
BACKGROUND: The recent COVID-19 outbreak in Wuhan, China, has quickly spread throughout the world. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19. METHODS: PubMed, Web of Science, EMBASE and MEDLINE were searched from January 1, 2020, to...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396931/ https://www.ncbi.nlm.nih.gov/pubmed/32746801 http://dx.doi.org/10.1186/s12879-020-05274-2 |
_version_ | 1783565669728518144 |
---|---|
author | Gao, Yi-jie Ye, Lei Zhang, Jia-shuo Yin, Yang-xue Liu, Min Yu, Hong-biao Zhou, Rong |
author_facet | Gao, Yi-jie Ye, Lei Zhang, Jia-shuo Yin, Yang-xue Liu, Min Yu, Hong-biao Zhou, Rong |
author_sort | Gao, Yi-jie |
collection | PubMed |
description | BACKGROUND: The recent COVID-19 outbreak in Wuhan, China, has quickly spread throughout the world. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19. METHODS: PubMed, Web of Science, EMBASE and MEDLINE were searched from January 1, 2020, to April 16, 2020. Case reports and case series of pregnant women infected with SARS-CoV-2 were included. Two reviewers screened 366 studies and 14 studies were included. Four reviewers independently extracted the features from the studies. We used a random-effects model to analyse the incidence (P) and 95% confidence interval (95% CI). Heterogeneity was assessed using the I(2) statistic. RESULTS: The meta-analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95% CI, 0.49–0.93), caesarean section (65%; 95% CI, 0.42–0.87), fever (51%; 95% CI, 0.35–0.67), lymphopenia (49%; 95% CI, 0.29–0.70), coexisting disorders (33%; 95% CI, 0.21–0.44), cough (31%; 95% CI, 0.23–0.39), fetal distress (29%; 95% CI, 0.08–0.49), preterm labor (23%; 95% CI, 0.14–0.32), and severe case or death (12%; 95% CI, 0.03–0.20). The subgroup analysis showed that compared with non-pregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever (pregnant women, 51%; non-pregnant patients, 91%; P < 0.00001) and cough (pregnant women, 31%; non-pregnant patients, 67%; P < 0.0001). CONCLUSIONS: The incidences of fever, cough and positive CT findings in pregnant women with COVID-19 are less than those in the normal population with COVID-19, but the rate of preterm labor is higher among pregnant with COVID-19 than among normal pregnant women. There is currently no evidence that COVID-19 can spread through vertical transmission. |
format | Online Article Text |
id | pubmed-7396931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73969312020-08-03 Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis Gao, Yi-jie Ye, Lei Zhang, Jia-shuo Yin, Yang-xue Liu, Min Yu, Hong-biao Zhou, Rong BMC Infect Dis Research Article BACKGROUND: The recent COVID-19 outbreak in Wuhan, China, has quickly spread throughout the world. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19. METHODS: PubMed, Web of Science, EMBASE and MEDLINE were searched from January 1, 2020, to April 16, 2020. Case reports and case series of pregnant women infected with SARS-CoV-2 were included. Two reviewers screened 366 studies and 14 studies were included. Four reviewers independently extracted the features from the studies. We used a random-effects model to analyse the incidence (P) and 95% confidence interval (95% CI). Heterogeneity was assessed using the I(2) statistic. RESULTS: The meta-analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95% CI, 0.49–0.93), caesarean section (65%; 95% CI, 0.42–0.87), fever (51%; 95% CI, 0.35–0.67), lymphopenia (49%; 95% CI, 0.29–0.70), coexisting disorders (33%; 95% CI, 0.21–0.44), cough (31%; 95% CI, 0.23–0.39), fetal distress (29%; 95% CI, 0.08–0.49), preterm labor (23%; 95% CI, 0.14–0.32), and severe case or death (12%; 95% CI, 0.03–0.20). The subgroup analysis showed that compared with non-pregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever (pregnant women, 51%; non-pregnant patients, 91%; P < 0.00001) and cough (pregnant women, 31%; non-pregnant patients, 67%; P < 0.0001). CONCLUSIONS: The incidences of fever, cough and positive CT findings in pregnant women with COVID-19 are less than those in the normal population with COVID-19, but the rate of preterm labor is higher among pregnant with COVID-19 than among normal pregnant women. There is currently no evidence that COVID-19 can spread through vertical transmission. BioMed Central 2020-08-03 /pmc/articles/PMC7396931/ /pubmed/32746801 http://dx.doi.org/10.1186/s12879-020-05274-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Gao, Yi-jie Ye, Lei Zhang, Jia-shuo Yin, Yang-xue Liu, Min Yu, Hong-biao Zhou, Rong Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title | Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title_full | Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title_fullStr | Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title_full_unstemmed | Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title_short | Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis |
title_sort | clinical features and outcomes of pregnant women with covid-19: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396931/ https://www.ncbi.nlm.nih.gov/pubmed/32746801 http://dx.doi.org/10.1186/s12879-020-05274-2 |
work_keys_str_mv | AT gaoyijie clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT yelei clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT zhangjiashuo clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT yinyangxue clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT liumin clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT yuhongbiao clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis AT zhourong clinicalfeaturesandoutcomesofpregnantwomenwithcovid19asystematicreviewandmetaanalysis |