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Internalized Functional DNA Aptamers as Alternative Cancer Therapies
Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To mee...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396948/ https://www.ncbi.nlm.nih.gov/pubmed/32848740 http://dx.doi.org/10.3389/fphar.2020.01115 |
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author | Marshall, Morgan L. Wagstaff, Kylie M. |
author_facet | Marshall, Morgan L. Wagstaff, Kylie M. |
author_sort | Marshall, Morgan L. |
collection | PubMed |
description | Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern healthcare requirements, it is essential to develop precision therapeutics that minimise off-target side-effects for various cancer types. To this end, highly specific molecular targeting agents against cancer are of great interest. These agents may work by targeting intracellular signalling pathways following receptor binding, or via internalization and targeting to specific subcellular compartments. DNA aptamers represent a promising molecular tool in this arena that can be used for both specific cell surface targeting and subsequent internalization and can also elicit a functional effect upon internalization. This review examines various cancer targeting cell-internalizing aptamers, with a particular focus towards functional aptamers that do not require additional conjugation to nanoparticles or small molecules to elicit a biological response. With a deeper understanding and precise exploitation of cancer specific molecular pathways, functional intracellular DNA aptamers may be a powerful step towards more widespread development of precision therapeutics. |
format | Online Article Text |
id | pubmed-7396948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73969482020-08-25 Internalized Functional DNA Aptamers as Alternative Cancer Therapies Marshall, Morgan L. Wagstaff, Kylie M. Front Pharmacol Pharmacology Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern healthcare requirements, it is essential to develop precision therapeutics that minimise off-target side-effects for various cancer types. To this end, highly specific molecular targeting agents against cancer are of great interest. These agents may work by targeting intracellular signalling pathways following receptor binding, or via internalization and targeting to specific subcellular compartments. DNA aptamers represent a promising molecular tool in this arena that can be used for both specific cell surface targeting and subsequent internalization and can also elicit a functional effect upon internalization. This review examines various cancer targeting cell-internalizing aptamers, with a particular focus towards functional aptamers that do not require additional conjugation to nanoparticles or small molecules to elicit a biological response. With a deeper understanding and precise exploitation of cancer specific molecular pathways, functional intracellular DNA aptamers may be a powerful step towards more widespread development of precision therapeutics. Frontiers Media S.A. 2020-07-24 /pmc/articles/PMC7396948/ /pubmed/32848740 http://dx.doi.org/10.3389/fphar.2020.01115 Text en Copyright © 2020 Marshall and Wagstaff http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Marshall, Morgan L. Wagstaff, Kylie M. Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title | Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title_full | Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title_fullStr | Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title_full_unstemmed | Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title_short | Internalized Functional DNA Aptamers as Alternative Cancer Therapies |
title_sort | internalized functional dna aptamers as alternative cancer therapies |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396948/ https://www.ncbi.nlm.nih.gov/pubmed/32848740 http://dx.doi.org/10.3389/fphar.2020.01115 |
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