The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes

The coordination chemistry of magnesium (Mg(2+)) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency (hypomagne...

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Detalles Bibliográficos
Autores principales: Case, Derek R., Zubieta, Jon, P. Doyle, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397051/
https://www.ncbi.nlm.nih.gov/pubmed/32664540
http://dx.doi.org/10.3390/molecules25143172
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author Case, Derek R.
Zubieta, Jon
P. Doyle, Robert
author_facet Case, Derek R.
Zubieta, Jon
P. Doyle, Robert
author_sort Case, Derek R.
collection PubMed
description The coordination chemistry of magnesium (Mg(2+)) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.
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spelling pubmed-73970512020-08-05 The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes Case, Derek R. Zubieta, Jon P. Doyle, Robert Molecules Review The coordination chemistry of magnesium (Mg(2+)) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry. MDPI 2020-07-11 /pmc/articles/PMC7397051/ /pubmed/32664540 http://dx.doi.org/10.3390/molecules25143172 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Case, Derek R.
Zubieta, Jon
P. Doyle, Robert
The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title_full The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title_fullStr The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title_full_unstemmed The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title_short The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes
title_sort coordination chemistry of bio-relevant ligands and their magnesium complexes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397051/
https://www.ncbi.nlm.nih.gov/pubmed/32664540
http://dx.doi.org/10.3390/molecules25143172
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