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Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic element...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397125/ https://www.ncbi.nlm.nih.gov/pubmed/32708659 http://dx.doi.org/10.3390/genes11070808 |
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author | Zouggar, Aïcha Haebe, Joshua R. Benoit, Yannick D. |
author_facet | Zouggar, Aïcha Haebe, Joshua R. Benoit, Yannick D. |
author_sort | Zouggar, Aïcha |
collection | PubMed |
description | In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease. |
format | Online Article Text |
id | pubmed-7397125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73971252020-08-05 Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer Zouggar, Aïcha Haebe, Joshua R. Benoit, Yannick D. Genes (Basel) Commentary In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease. MDPI 2020-07-16 /pmc/articles/PMC7397125/ /pubmed/32708659 http://dx.doi.org/10.3390/genes11070808 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Zouggar, Aïcha Haebe, Joshua R. Benoit, Yannick D. Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title_full | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title_fullStr | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title_full_unstemmed | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title_short | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
title_sort | intestinal microbiota influences dna methylome and susceptibility to colorectal cancer |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397125/ https://www.ncbi.nlm.nih.gov/pubmed/32708659 http://dx.doi.org/10.3390/genes11070808 |
work_keys_str_mv | AT zouggaraicha intestinalmicrobiotainfluencesdnamethylomeandsusceptibilitytocolorectalcancer AT haebejoshuar intestinalmicrobiotainfluencesdnamethylomeandsusceptibilitytocolorectalcancer AT benoityannickd intestinalmicrobiotainfluencesdnamethylomeandsusceptibilitytocolorectalcancer |