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Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic element...

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Detalles Bibliográficos
Autores principales: Zouggar, Aïcha, Haebe, Joshua R., Benoit, Yannick D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397125/
https://www.ncbi.nlm.nih.gov/pubmed/32708659
http://dx.doi.org/10.3390/genes11070808
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author Zouggar, Aïcha
Haebe, Joshua R.
Benoit, Yannick D.
author_facet Zouggar, Aïcha
Haebe, Joshua R.
Benoit, Yannick D.
author_sort Zouggar, Aïcha
collection PubMed
description In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease.
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spelling pubmed-73971252020-08-05 Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer Zouggar, Aïcha Haebe, Joshua R. Benoit, Yannick D. Genes (Basel) Commentary In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease. MDPI 2020-07-16 /pmc/articles/PMC7397125/ /pubmed/32708659 http://dx.doi.org/10.3390/genes11070808 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Zouggar, Aïcha
Haebe, Joshua R.
Benoit, Yannick D.
Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title_full Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title_fullStr Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title_full_unstemmed Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title_short Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
title_sort intestinal microbiota influences dna methylome and susceptibility to colorectal cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397125/
https://www.ncbi.nlm.nih.gov/pubmed/32708659
http://dx.doi.org/10.3390/genes11070808
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