Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor(®)

New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor(®). These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the...

Descripción completa

Detalles Bibliográficos
Autores principales: Pikun, Nadiia V., Sobolev, Arkadij, Plotniece, Aiva, Rucins, Martins, Vigante, Brigita, Petrova, Marina, Muhamadejev, Ruslan, Pajuste, Karlis, Shermolovich, Yuriy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397266/
https://www.ncbi.nlm.nih.gov/pubmed/32660085
http://dx.doi.org/10.3390/molecules25143143
Descripción
Sumario:New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor(®). These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor(®) has been developed.

Ejemplares similares