Cargando…

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for...

Descripción completa

Detalles Bibliográficos
Autores principales: Malhotra, Nemi, Lee, Jiann-Shing, Liman, Rhenz Alfred D., Ruallo, Johnsy Margotte S., Villaflores, Oliver B., Ger, Tzong-Rong, Hsiao, Chung-Der
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397295/
https://www.ncbi.nlm.nih.gov/pubmed/32664325
http://dx.doi.org/10.3390/molecules25143159
_version_ 1783565748137885696
author Malhotra, Nemi
Lee, Jiann-Shing
Liman, Rhenz Alfred D.
Ruallo, Johnsy Margotte S.
Villaflores, Oliver B.
Ger, Tzong-Rong
Hsiao, Chung-Der
author_facet Malhotra, Nemi
Lee, Jiann-Shing
Liman, Rhenz Alfred D.
Ruallo, Johnsy Margotte S.
Villaflores, Oliver B.
Ger, Tzong-Rong
Hsiao, Chung-Der
author_sort Malhotra, Nemi
collection PubMed
description The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.
format Online
Article
Text
id pubmed-7397295
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73972952020-08-16 Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review Malhotra, Nemi Lee, Jiann-Shing Liman, Rhenz Alfred D. Ruallo, Johnsy Margotte S. Villaflores, Oliver B. Ger, Tzong-Rong Hsiao, Chung-Der Molecules Review The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction. MDPI 2020-07-10 /pmc/articles/PMC7397295/ /pubmed/32664325 http://dx.doi.org/10.3390/molecules25143159 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malhotra, Nemi
Lee, Jiann-Shing
Liman, Rhenz Alfred D.
Ruallo, Johnsy Margotte S.
Villaflores, Oliver B.
Ger, Tzong-Rong
Hsiao, Chung-Der
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title_full Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title_fullStr Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title_full_unstemmed Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title_short Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
title_sort potential toxicity of iron oxide magnetic nanoparticles: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397295/
https://www.ncbi.nlm.nih.gov/pubmed/32664325
http://dx.doi.org/10.3390/molecules25143159
work_keys_str_mv AT malhotranemi potentialtoxicityofironoxidemagneticnanoparticlesareview
AT leejiannshing potentialtoxicityofironoxidemagneticnanoparticlesareview
AT limanrhenzalfredd potentialtoxicityofironoxidemagneticnanoparticlesareview
AT ruallojohnsymargottes potentialtoxicityofironoxidemagneticnanoparticlesareview
AT villafloresoliverb potentialtoxicityofironoxidemagneticnanoparticlesareview
AT gertzongrong potentialtoxicityofironoxidemagneticnanoparticlesareview
AT hsiaochungder potentialtoxicityofironoxidemagneticnanoparticlesareview