Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors

Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhi...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Zhang, Wenjin, Peng, Yi, Jiang, Zhi-Hong, Zhang, Lanyue, Du, Zhiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397320/
https://www.ncbi.nlm.nih.gov/pubmed/32664629
http://dx.doi.org/10.3390/molecules25143180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397320/
https://www.ncbi.nlm.nih.gov/pubmed/32664629
http://dx.doi.org/10.3390/molecules25143180

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