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Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors

Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhi...

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Detalles Bibliográficos
Autores principales:	Zhou, Wei, Zhang, Wenjin, Peng, Yi, Jiang, Zhi-Hong, Zhang, Lanyue, Du, Zhiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397320/ https://www.ncbi.nlm.nih.gov/pubmed/32664629 http://dx.doi.org/10.3390/molecules25143180

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