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The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction

PURPOSE: This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. METHODS: A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total...

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Autores principales: Zu, Hongliang, Wang, Huiling, Li, Chunfeng, Zhu, Wendian, Xue, Yingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397385/
https://www.ncbi.nlm.nih.gov/pubmed/32774358
http://dx.doi.org/10.1155/2020/6529563
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author Zu, Hongliang
Wang, Huiling
Li, Chunfeng
Zhu, Wendian
Xue, Yingwei
author_facet Zu, Hongliang
Wang, Huiling
Li, Chunfeng
Zhu, Wendian
Xue, Yingwei
author_sort Zu, Hongliang
collection PubMed
description PURPOSE: This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. METHODS: A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total, 157 patients had GOO. The clinicopathological features of the patients with GOO were compared with those of the patients without GOO. A Kaplan-Meier survival analysis and Cox proportional hazard model were used to assess the overall survival. RESULTS: The patients with distal gastric cancer with GOO generally presented more aggressive pathologic features, a poorer nutritional status, more duodenal infiltration, and peritoneal dissemination than those with cancer without GOO. In the univariate analysis, curability, GOO, age, prealbumin, albumin, hemoglobin (Hb), the tumor size, the macroscopic type, lymph node metastasis, and the depth of invasion had a statistically significant influence on prognosis. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. CONCLUSIONS: Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. The gastric outlet status should be considered in the selection of surgical treatment methods for patients with gastric cancer.
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spelling pubmed-73973852020-08-07 The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction Zu, Hongliang Wang, Huiling Li, Chunfeng Zhu, Wendian Xue, Yingwei Gastroenterol Res Pract Research Article PURPOSE: This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. METHODS: A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total, 157 patients had GOO. The clinicopathological features of the patients with GOO were compared with those of the patients without GOO. A Kaplan-Meier survival analysis and Cox proportional hazard model were used to assess the overall survival. RESULTS: The patients with distal gastric cancer with GOO generally presented more aggressive pathologic features, a poorer nutritional status, more duodenal infiltration, and peritoneal dissemination than those with cancer without GOO. In the univariate analysis, curability, GOO, age, prealbumin, albumin, hemoglobin (Hb), the tumor size, the macroscopic type, lymph node metastasis, and the depth of invasion had a statistically significant influence on prognosis. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. CONCLUSIONS: Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. The gastric outlet status should be considered in the selection of surgical treatment methods for patients with gastric cancer. Hindawi 2020-07-25 /pmc/articles/PMC7397385/ /pubmed/32774358 http://dx.doi.org/10.1155/2020/6529563 Text en Copyright © 2020 Hongliang Zu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zu, Hongliang
Wang, Huiling
Li, Chunfeng
Zhu, Wendian
Xue, Yingwei
The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title_full The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title_fullStr The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title_full_unstemmed The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title_short The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
title_sort predictive and prognostic factors in patients with gastric cancer accompanied by gastric outlet obstruction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397385/
https://www.ncbi.nlm.nih.gov/pubmed/32774358
http://dx.doi.org/10.1155/2020/6529563
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