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Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall

Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive, soft tissue sarcoma that is often fatal. Although there are reports describing associations of sarcoma and skin lesions such as burns, radiation, and trauma, to our knowledge, UPS development in a keloid scar has not been report...

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Autores principales: Kinoshita, Hideyuki, Tsukanishi, Toshinori, Ishii, Takeshi, Kamoda, Hiroto, Hagiwara, Yoko, Orita, Sumihisa, Inage, Kazuhide, Hirosawa, Naoya, Ohtori, Seiji, Yonemoto, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397415/
https://www.ncbi.nlm.nih.gov/pubmed/32774941
http://dx.doi.org/10.1155/2020/4898965
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author Kinoshita, Hideyuki
Tsukanishi, Toshinori
Ishii, Takeshi
Kamoda, Hiroto
Hagiwara, Yoko
Orita, Sumihisa
Inage, Kazuhide
Hirosawa, Naoya
Ohtori, Seiji
Yonemoto, Tsukasa
author_facet Kinoshita, Hideyuki
Tsukanishi, Toshinori
Ishii, Takeshi
Kamoda, Hiroto
Hagiwara, Yoko
Orita, Sumihisa
Inage, Kazuhide
Hirosawa, Naoya
Ohtori, Seiji
Yonemoto, Tsukasa
author_sort Kinoshita, Hideyuki
collection PubMed
description Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive, soft tissue sarcoma that is often fatal. Although there are reports describing associations of sarcoma and skin lesions such as burns, radiation, and trauma, to our knowledge, UPS development in a keloid scar has not been reported. Herein, we present the case of a 76-year-old woman who had undergone surgery for endometrial cancer, 5 years before. She presented with a protruding lesion that was continuous to a keloid scar on the abdominal wall. The tumor appeared clinically malignant as it was protruding and doubled in size within three weeks, reaching approximately 6 × 6 × 2 cm. Since the tumor was diagnosed as UPS after pathological evaluation by needle biopsy, wide resection was performed. Intraoperatively, the tumor was apparently continuous to the keloid, protruding and pedunculated outside the body, and had not invaded the abdominal cavity. Histopathological examination of the resected tumor showed evidence of UPS and no suspicion of metastasis of endometrial cancer. No recurrence, metastases, or other complications were noted 6 months after surgery. The current case study reminds us that keloids may cause high-grade sarcoma such as UPS, and careful follow-up is required.
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spelling pubmed-73974152020-08-07 Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall Kinoshita, Hideyuki Tsukanishi, Toshinori Ishii, Takeshi Kamoda, Hiroto Hagiwara, Yoko Orita, Sumihisa Inage, Kazuhide Hirosawa, Naoya Ohtori, Seiji Yonemoto, Tsukasa Case Rep Dermatol Med Case Report Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive, soft tissue sarcoma that is often fatal. Although there are reports describing associations of sarcoma and skin lesions such as burns, radiation, and trauma, to our knowledge, UPS development in a keloid scar has not been reported. Herein, we present the case of a 76-year-old woman who had undergone surgery for endometrial cancer, 5 years before. She presented with a protruding lesion that was continuous to a keloid scar on the abdominal wall. The tumor appeared clinically malignant as it was protruding and doubled in size within three weeks, reaching approximately 6 × 6 × 2 cm. Since the tumor was diagnosed as UPS after pathological evaluation by needle biopsy, wide resection was performed. Intraoperatively, the tumor was apparently continuous to the keloid, protruding and pedunculated outside the body, and had not invaded the abdominal cavity. Histopathological examination of the resected tumor showed evidence of UPS and no suspicion of metastasis of endometrial cancer. No recurrence, metastases, or other complications were noted 6 months after surgery. The current case study reminds us that keloids may cause high-grade sarcoma such as UPS, and careful follow-up is required. Hindawi 2020-07-24 /pmc/articles/PMC7397415/ /pubmed/32774941 http://dx.doi.org/10.1155/2020/4898965 Text en Copyright © 2020 Hideyuki Kinoshita et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kinoshita, Hideyuki
Tsukanishi, Toshinori
Ishii, Takeshi
Kamoda, Hiroto
Hagiwara, Yoko
Orita, Sumihisa
Inage, Kazuhide
Hirosawa, Naoya
Ohtori, Seiji
Yonemoto, Tsukasa
Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title_full Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title_fullStr Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title_full_unstemmed Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title_short Giant Protruding High-Grade Undifferentiated Pleomorphic Sarcoma Arising in a Keloid Scar on the Abdominal Wall
title_sort giant protruding high-grade undifferentiated pleomorphic sarcoma arising in a keloid scar on the abdominal wall
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397415/
https://www.ncbi.nlm.nih.gov/pubmed/32774941
http://dx.doi.org/10.1155/2020/4898965
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