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Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review

Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell target...

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Autores principales: Shaher, Fahmi, Qiu, Hongbin, Wang, Shuqiu, Hu, Yu, Wang, Weiqun, Zhang, Yu, Wei, Yao, AL-ward, Hisham, Abdulghani, Mahfoudh A. M., Alenezi, Sattam Khulaif, Baldi, Salem, Zhou, Shaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397440/
https://www.ncbi.nlm.nih.gov/pubmed/32775437
http://dx.doi.org/10.1155/2020/7136075
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author Shaher, Fahmi
Qiu, Hongbin
Wang, Shuqiu
Hu, Yu
Wang, Weiqun
Zhang, Yu
Wei, Yao
AL-ward, Hisham
Abdulghani, Mahfoudh A. M.
Alenezi, Sattam Khulaif
Baldi, Salem
Zhou, Shaobo
author_facet Shaher, Fahmi
Qiu, Hongbin
Wang, Shuqiu
Hu, Yu
Wang, Weiqun
Zhang, Yu
Wei, Yao
AL-ward, Hisham
Abdulghani, Mahfoudh A. M.
Alenezi, Sattam Khulaif
Baldi, Salem
Zhou, Shaobo
author_sort Shaher, Fahmi
collection PubMed
description Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways.
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spelling pubmed-73974402020-08-07 Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review Shaher, Fahmi Qiu, Hongbin Wang, Shuqiu Hu, Yu Wang, Weiqun Zhang, Yu Wei, Yao AL-ward, Hisham Abdulghani, Mahfoudh A. M. Alenezi, Sattam Khulaif Baldi, Salem Zhou, Shaobo Biomed Res Int Review Article Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways. Hindawi 2020-07-25 /pmc/articles/PMC7397440/ /pubmed/32775437 http://dx.doi.org/10.1155/2020/7136075 Text en Copyright © 2020 Fahmi Shaher et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shaher, Fahmi
Qiu, Hongbin
Wang, Shuqiu
Hu, Yu
Wang, Weiqun
Zhang, Yu
Wei, Yao
AL-ward, Hisham
Abdulghani, Mahfoudh A. M.
Alenezi, Sattam Khulaif
Baldi, Salem
Zhou, Shaobo
Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title_full Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title_fullStr Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title_full_unstemmed Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title_short Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
title_sort associated targets of the antioxidant cardioprotection of ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397440/
https://www.ncbi.nlm.nih.gov/pubmed/32775437
http://dx.doi.org/10.1155/2020/7136075
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