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Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell target...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397440/ https://www.ncbi.nlm.nih.gov/pubmed/32775437 http://dx.doi.org/10.1155/2020/7136075 |
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author | Shaher, Fahmi Qiu, Hongbin Wang, Shuqiu Hu, Yu Wang, Weiqun Zhang, Yu Wei, Yao AL-ward, Hisham Abdulghani, Mahfoudh A. M. Alenezi, Sattam Khulaif Baldi, Salem Zhou, Shaobo |
author_facet | Shaher, Fahmi Qiu, Hongbin Wang, Shuqiu Hu, Yu Wang, Weiqun Zhang, Yu Wei, Yao AL-ward, Hisham Abdulghani, Mahfoudh A. M. Alenezi, Sattam Khulaif Baldi, Salem Zhou, Shaobo |
author_sort | Shaher, Fahmi |
collection | PubMed |
description | Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways. |
format | Online Article Text |
id | pubmed-7397440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73974402020-08-07 Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review Shaher, Fahmi Qiu, Hongbin Wang, Shuqiu Hu, Yu Wang, Weiqun Zhang, Yu Wei, Yao AL-ward, Hisham Abdulghani, Mahfoudh A. M. Alenezi, Sattam Khulaif Baldi, Salem Zhou, Shaobo Biomed Res Int Review Article Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways. Hindawi 2020-07-25 /pmc/articles/PMC7397440/ /pubmed/32775437 http://dx.doi.org/10.1155/2020/7136075 Text en Copyright © 2020 Fahmi Shaher et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shaher, Fahmi Qiu, Hongbin Wang, Shuqiu Hu, Yu Wang, Weiqun Zhang, Yu Wei, Yao AL-ward, Hisham Abdulghani, Mahfoudh A. M. Alenezi, Sattam Khulaif Baldi, Salem Zhou, Shaobo Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title | Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title_full | Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title_fullStr | Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title_full_unstemmed | Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title_short | Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review |
title_sort | associated targets of the antioxidant cardioprotection of ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397440/ https://www.ncbi.nlm.nih.gov/pubmed/32775437 http://dx.doi.org/10.1155/2020/7136075 |
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