Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Diabetic kidney disease (DKD) increases the risk for mortality and is the leading cause of end-stage renal disease. Treatment with sodium-glucose cotransporter 2 inhibitors (SGLT2i) attenuates the progression of DKD, especially in patients with advanced kidney disease. Herein, we show that in diabet...

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Detalles Bibliográficos
Autores principales: Kogot-Levin, Aviram, Hinden, Liad, Riahi, Yael, Israeli, Tal, Tirosh, Boaz, Cerasi, Erol, Mizrachi, Ernesto Bernal, Tam, Joseph, Mosenzon, Ofri, Leibowitz, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397516/
https://www.ncbi.nlm.nih.gov/pubmed/32726619
http://dx.doi.org/10.1016/j.celrep.2020.107954

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