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Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study

OBJECTIVE: The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. METHODS: All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by us...

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Autores principales: Do, Minh Duc, Mai, Thao Phuong, Do, Anh Duy, Nguyen, Quang Dinh, Le, Nghia Hieu, Le, Linh Gia Hoang, Hoang, Vu Anh, Le, Anh Ngoc, Le, Hung Quoc, Richette, Pascal, Resche-Rigon, Matthieu, Bardin, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397637/
https://www.ncbi.nlm.nih.gov/pubmed/32746911
http://dx.doi.org/10.1186/s13075-020-02273-1
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author Do, Minh Duc
Mai, Thao Phuong
Do, Anh Duy
Nguyen, Quang Dinh
Le, Nghia Hieu
Le, Linh Gia Hoang
Hoang, Vu Anh
Le, Anh Ngoc
Le, Hung Quoc
Richette, Pascal
Resche-Rigon, Matthieu
Bardin, Thomas
author_facet Do, Minh Duc
Mai, Thao Phuong
Do, Anh Duy
Nguyen, Quang Dinh
Le, Nghia Hieu
Le, Linh Gia Hoang
Hoang, Vu Anh
Le, Anh Ngoc
Le, Hung Quoc
Richette, Pascal
Resche-Rigon, Matthieu
Bardin, Thomas
author_sort Do, Minh Duc
collection PubMed
description OBJECTIVE: The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. METHODS: All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. RESULTS: On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8–40.1], P < 0.0001), female sex (OR 333 [40–43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120–125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101–122], P < 0.0001), diuretics intake (OR 304 [35–40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m(2) (OR 100 [32–353], P < 0.0001), history of allopurinol-induced skin reaction (OR 78 [6–10,808], P = 0.004), and HLA-B*58:01 carriage (OR 147 [45–746], P < 0.0001). HLA-B*58:01 allele frequency in controls was 7.3%. For MCARs (n = 74), risk factors were eGFR < 60 ml/min/1.73 m(2) (OR 4.9 [1.61–14.6], P = 0.006), history of allopurinol-induced skin reaction (OR 27 [2–3777], P = 0.01), and asymptomatic hyperuricemia (OR 27 [2–3777], P = 0.01). CONCLUSION: This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout.
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spelling pubmed-73976372020-08-06 Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study Do, Minh Duc Mai, Thao Phuong Do, Anh Duy Nguyen, Quang Dinh Le, Nghia Hieu Le, Linh Gia Hoang Hoang, Vu Anh Le, Anh Ngoc Le, Hung Quoc Richette, Pascal Resche-Rigon, Matthieu Bardin, Thomas Arthritis Res Ther Research Article OBJECTIVE: The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese. METHODS: All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. RESULTS: On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8–40.1], P < 0.0001), female sex (OR 333 [40–43,453], P < 0.0001), allopurinol for asymptomatic hyperuricemia (OR 955 [120–125,847], P < 0.0001), allopurinol starting dose > 150 mg (OR 316 [101–122], P < 0.0001), diuretics intake (OR 304 [35–40,018], P < 0.0001), eGFR < 60 ml/min/1.73 m(2) (OR 100 [32–353], P < 0.0001), history of allopurinol-induced skin reaction (OR 78 [6–10,808], P = 0.004), and HLA-B*58:01 carriage (OR 147 [45–746], P < 0.0001). HLA-B*58:01 allele frequency in controls was 7.3%. For MCARs (n = 74), risk factors were eGFR < 60 ml/min/1.73 m(2) (OR 4.9 [1.61–14.6], P = 0.006), history of allopurinol-induced skin reaction (OR 27 [2–3777], P = 0.01), and asymptomatic hyperuricemia (OR 27 [2–3777], P = 0.01). CONCLUSION: This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. HLA-B*58:01 genotyping could guide the indication for allopurinol in Kinh Vietnamese patients with gout. BioMed Central 2020-08-03 2020 /pmc/articles/PMC7397637/ /pubmed/32746911 http://dx.doi.org/10.1186/s13075-020-02273-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Do, Minh Duc
Mai, Thao Phuong
Do, Anh Duy
Nguyen, Quang Dinh
Le, Nghia Hieu
Le, Linh Gia Hoang
Hoang, Vu Anh
Le, Anh Ngoc
Le, Hung Quoc
Richette, Pascal
Resche-Rigon, Matthieu
Bardin, Thomas
Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title_full Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title_fullStr Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title_full_unstemmed Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title_short Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study
title_sort risk factors for cutaneous reactions to allopurinol in kinh vietnamese: results from a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397637/
https://www.ncbi.nlm.nih.gov/pubmed/32746911
http://dx.doi.org/10.1186/s13075-020-02273-1
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