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Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy

Craniopharyngiomas can invade surrounding structures, including the optic chiasm and hypothalamus. In such cases, subtotal resection is often preferred to limit perioperative morbidity and mortality; however, subtotal resection is associated with high rates of recurrence. Recurrent craniopharyngioma...

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Autores principales: Burgess, Laura, Chakraborty, Santanu, Malone, Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397706/
https://www.ncbi.nlm.nih.gov/pubmed/32774574
http://dx.doi.org/10.1016/j.radcr.2020.07.015
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author Burgess, Laura
Chakraborty, Santanu
Malone, Shawn
author_facet Burgess, Laura
Chakraborty, Santanu
Malone, Shawn
author_sort Burgess, Laura
collection PubMed
description Craniopharyngiomas can invade surrounding structures, including the optic chiasm and hypothalamus. In such cases, subtotal resection is often preferred to limit perioperative morbidity and mortality; however, subtotal resection is associated with high rates of recurrence. Recurrent craniopharyngioma is typically treated with another subtotal resection and adjuvant radiotherapy. We present a case of a patient found to have a large craniopharyngioma compressing the optic chiasm, hypothalamus and left cavernous sinus. She underwent surgical debulking but developed recurrence shortly thereafter. Subsequently, she underwent a second debulking surgery, followed by fractionated stereotactic radiotherapy (SRT). Results show that she exhibited an impressive response to SRT with further tumor shrinkage, while remaining clinically well. This case demonstrates the efficacy of SRT in salvage of recurrent craniopharyngioma.
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spelling pubmed-73977062020-08-06 Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy Burgess, Laura Chakraborty, Santanu Malone, Shawn Radiol Case Rep Neuroradiology Craniopharyngiomas can invade surrounding structures, including the optic chiasm and hypothalamus. In such cases, subtotal resection is often preferred to limit perioperative morbidity and mortality; however, subtotal resection is associated with high rates of recurrence. Recurrent craniopharyngioma is typically treated with another subtotal resection and adjuvant radiotherapy. We present a case of a patient found to have a large craniopharyngioma compressing the optic chiasm, hypothalamus and left cavernous sinus. She underwent surgical debulking but developed recurrence shortly thereafter. Subsequently, she underwent a second debulking surgery, followed by fractionated stereotactic radiotherapy (SRT). Results show that she exhibited an impressive response to SRT with further tumor shrinkage, while remaining clinically well. This case demonstrates the efficacy of SRT in salvage of recurrent craniopharyngioma. Elsevier 2020-08-02 /pmc/articles/PMC7397706/ /pubmed/32774574 http://dx.doi.org/10.1016/j.radcr.2020.07.015 Text en © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Neuroradiology
Burgess, Laura
Chakraborty, Santanu
Malone, Shawn
Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title_full Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title_fullStr Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title_full_unstemmed Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title_short Effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
title_sort effective salvage of recurrent craniopharyngioma with fractionated stereotactic radiotherapy
topic Neuroradiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397706/
https://www.ncbi.nlm.nih.gov/pubmed/32774574
http://dx.doi.org/10.1016/j.radcr.2020.07.015
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