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Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome
Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397854/ https://www.ncbi.nlm.nih.gov/pubmed/32747477 http://dx.doi.org/10.1101/gad.338962.120 |
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author | Cherry, Sara Lynch, Kristen W. |
author_facet | Cherry, Sara Lynch, Kristen W. |
author_sort | Cherry, Sara |
collection | PubMed |
description | Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer. |
format | Online Article Text |
id | pubmed-7397854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73978542021-02-01 Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome Cherry, Sara Lynch, Kristen W. Genes Dev Review Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer. Cold Spring Harbor Laboratory Press 2020-08-01 /pmc/articles/PMC7397854/ /pubmed/32747477 http://dx.doi.org/10.1101/gad.338962.120 Text en © 2020 Cherry and Lynch; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Cherry, Sara Lynch, Kristen W. Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title | Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title_full | Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title_fullStr | Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title_full_unstemmed | Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title_short | Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
title_sort | alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397854/ https://www.ncbi.nlm.nih.gov/pubmed/32747477 http://dx.doi.org/10.1101/gad.338962.120 |
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