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Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results
The aim of this study is to evaluate the effectiveness of rectal ozone (O(3)) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with re...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397966/ https://www.ncbi.nlm.nih.gov/pubmed/32838181 http://dx.doi.org/10.1007/s42399-020-00374-1 |
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author | Fernández-Cuadros, Marcos Edgar Albaladejo-Florín, María Jesús Álava-Rabasa, Sandra Usandizaga-Elio, Isabel Martinez-Quintanilla Jimenez, Dolores Peña-Lora, Daiana Neira-Borrajo, Inmaculada López-Muñoz, María Jesús Rodríguez-de-Cía, Javier Pérez-Moro, Olga Susana |
author_facet | Fernández-Cuadros, Marcos Edgar Albaladejo-Florín, María Jesús Álava-Rabasa, Sandra Usandizaga-Elio, Isabel Martinez-Quintanilla Jimenez, Dolores Peña-Lora, Daiana Neira-Borrajo, Inmaculada López-Muñoz, María Jesús Rodríguez-de-Cía, Javier Pérez-Moro, Olga Susana |
author_sort | Fernández-Cuadros, Marcos Edgar |
collection | PubMed |
description | The aim of this study is to evaluate the effectiveness of rectal ozone (O(3)) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with rectal ozone and confirmed with (+) RT-PCR for SARS-CoV-2 and evaluated afterwards. The analyzed outcome variables were as follows: (a) clinical improvement (O(2) saturation and O(2) supply); (b) biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP); (c) radiological improvement. The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. The Protocol was previously approved by the Hospital’s Health Care Ethics Committee (CEAS) (Report 15/4/2020) for compassionate use in the face of this exceptional pandemic situation, and prior informed consent was obtained from the patient/legal representative. The patients improved oxygen saturation, as observed by the lower number of desaturations and the lower supply of O(2). Biomarkers of inflammation decreased (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP). Finally, the radiological signs of bilateral viral pneumonitis improved between 1 and 2 grades based on Taylor’s radiological scale. Rectal ozone decreases O(2) supply and improves O(2) saturation, decreases inflammation biomarkers, and improves Taylor’s radiological grade in patients with severe COVID-19 pneumonia. Rectal ozone is a safe, effective, cheap, and simple alternative capable of acting on the SARS-CoV-2 virus, and it is presented as an adjunctive therapeutic option to consider in the management of severe bilateral COVID-19 pneumonia. |
format | Online Article Text |
id | pubmed-7397966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73979662020-08-04 Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results Fernández-Cuadros, Marcos Edgar Albaladejo-Florín, María Jesús Álava-Rabasa, Sandra Usandizaga-Elio, Isabel Martinez-Quintanilla Jimenez, Dolores Peña-Lora, Daiana Neira-Borrajo, Inmaculada López-Muñoz, María Jesús Rodríguez-de-Cía, Javier Pérez-Moro, Olga Susana SN Compr Clin Med Covid-19 The aim of this study is to evaluate the effectiveness of rectal ozone (O(3)) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with rectal ozone and confirmed with (+) RT-PCR for SARS-CoV-2 and evaluated afterwards. The analyzed outcome variables were as follows: (a) clinical improvement (O(2) saturation and O(2) supply); (b) biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP); (c) radiological improvement. The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. The Protocol was previously approved by the Hospital’s Health Care Ethics Committee (CEAS) (Report 15/4/2020) for compassionate use in the face of this exceptional pandemic situation, and prior informed consent was obtained from the patient/legal representative. The patients improved oxygen saturation, as observed by the lower number of desaturations and the lower supply of O(2). Biomarkers of inflammation decreased (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP). Finally, the radiological signs of bilateral viral pneumonitis improved between 1 and 2 grades based on Taylor’s radiological scale. Rectal ozone decreases O(2) supply and improves O(2) saturation, decreases inflammation biomarkers, and improves Taylor’s radiological grade in patients with severe COVID-19 pneumonia. Rectal ozone is a safe, effective, cheap, and simple alternative capable of acting on the SARS-CoV-2 virus, and it is presented as an adjunctive therapeutic option to consider in the management of severe bilateral COVID-19 pneumonia. Springer International Publishing 2020-08-03 2020 /pmc/articles/PMC7397966/ /pubmed/32838181 http://dx.doi.org/10.1007/s42399-020-00374-1 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Covid-19 Fernández-Cuadros, Marcos Edgar Albaladejo-Florín, María Jesús Álava-Rabasa, Sandra Usandizaga-Elio, Isabel Martinez-Quintanilla Jimenez, Dolores Peña-Lora, Daiana Neira-Borrajo, Inmaculada López-Muñoz, María Jesús Rodríguez-de-Cía, Javier Pérez-Moro, Olga Susana Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title | Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title_full | Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title_fullStr | Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title_full_unstemmed | Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title_short | Effect of Rectal Ozone (O(3)) in Severe COVID-19 Pneumonia: Preliminary Results |
title_sort | effect of rectal ozone (o(3)) in severe covid-19 pneumonia: preliminary results |
topic | Covid-19 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397966/ https://www.ncbi.nlm.nih.gov/pubmed/32838181 http://dx.doi.org/10.1007/s42399-020-00374-1 |
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