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The crosstalk: exosomes and lipid metabolism

Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of the proteins and abundant lipid, enhancing their “rigidity” and “flexibility”. Neighboring...

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Autores principales: Wang, Wei, Zhu, Neng, Yan, Tao, Shi, Ya-Ning, Chen, Jing, Zhang, Chan-Juan, Xie, Xue-Jiao, Liao, Duan-Fang, Qin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398059/
https://www.ncbi.nlm.nih.gov/pubmed/32746850
http://dx.doi.org/10.1186/s12964-020-00581-2
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author Wang, Wei
Zhu, Neng
Yan, Tao
Shi, Ya-Ning
Chen, Jing
Zhang, Chan-Juan
Xie, Xue-Jiao
Liao, Duan-Fang
Qin, Li
author_facet Wang, Wei
Zhu, Neng
Yan, Tao
Shi, Ya-Ning
Chen, Jing
Zhang, Chan-Juan
Xie, Xue-Jiao
Liao, Duan-Fang
Qin, Li
author_sort Wang, Wei
collection PubMed
description Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of the proteins and abundant lipid, enhancing their “rigidity” and “flexibility”. Neighboring cells or distant cells are capable of exchanging genetic or metabolic information via exosomes binding to recipient cell and releasing bioactive molecules, such as lipids, proteins, and nucleic acids. Of note, exosomes exert the remarkable effects on lipid metabolism, including the synthesis, transportation and degradation of the lipid. The disorder of lipid metabolism mediated by exosomes leads to the occurrence and progression of diseases, such as atherosclerosis, cancer, non-alcoholic fatty liver disease (NAFLD), obesity and Alzheimer’s diseases and so on. More importantly, lipid metabolism can also affect the production and secretion of exosomes, as well as interactions with the recipient cells. Therefore, exosomes may be applied as effective targets for diagnosis and treatment of diseases.
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spelling pubmed-73980592020-08-06 The crosstalk: exosomes and lipid metabolism Wang, Wei Zhu, Neng Yan, Tao Shi, Ya-Ning Chen, Jing Zhang, Chan-Juan Xie, Xue-Jiao Liao, Duan-Fang Qin, Li Cell Commun Signal Review Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of the proteins and abundant lipid, enhancing their “rigidity” and “flexibility”. Neighboring cells or distant cells are capable of exchanging genetic or metabolic information via exosomes binding to recipient cell and releasing bioactive molecules, such as lipids, proteins, and nucleic acids. Of note, exosomes exert the remarkable effects on lipid metabolism, including the synthesis, transportation and degradation of the lipid. The disorder of lipid metabolism mediated by exosomes leads to the occurrence and progression of diseases, such as atherosclerosis, cancer, non-alcoholic fatty liver disease (NAFLD), obesity and Alzheimer’s diseases and so on. More importantly, lipid metabolism can also affect the production and secretion of exosomes, as well as interactions with the recipient cells. Therefore, exosomes may be applied as effective targets for diagnosis and treatment of diseases. BioMed Central 2020-08-03 /pmc/articles/PMC7398059/ /pubmed/32746850 http://dx.doi.org/10.1186/s12964-020-00581-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Wei
Zhu, Neng
Yan, Tao
Shi, Ya-Ning
Chen, Jing
Zhang, Chan-Juan
Xie, Xue-Jiao
Liao, Duan-Fang
Qin, Li
The crosstalk: exosomes and lipid metabolism
title The crosstalk: exosomes and lipid metabolism
title_full The crosstalk: exosomes and lipid metabolism
title_fullStr The crosstalk: exosomes and lipid metabolism
title_full_unstemmed The crosstalk: exosomes and lipid metabolism
title_short The crosstalk: exosomes and lipid metabolism
title_sort crosstalk: exosomes and lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398059/
https://www.ncbi.nlm.nih.gov/pubmed/32746850
http://dx.doi.org/10.1186/s12964-020-00581-2
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