Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action

Kv7 channels are powerfully regulated by a wide variety of physiological and pharmacological signals. Larsson et al. describe the direct modulation of Kv7 channels by endocannabinoids and explore how combinations of Kv7 activators with distinct subtype specificities might lead to effective and selec...

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Detalles Bibliográficos
Autor principal: Kurata, Harley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398145/
https://www.ncbi.nlm.nih.gov/pubmed/32484852
http://dx.doi.org/10.1085/jgp.202012598
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author Kurata, Harley T.
author_facet Kurata, Harley T.
author_sort Kurata, Harley T.
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description Kv7 channels are powerfully regulated by a wide variety of physiological and pharmacological signals. Larsson et al. describe the direct modulation of Kv7 channels by endocannabinoids and explore how combinations of Kv7 activators with distinct subtype specificities might lead to effective and selective drug cocktails.
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spelling pubmed-73981452021-02-03 Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action Kurata, Harley T. J Gen Physiol Commentary Kv7 channels are powerfully regulated by a wide variety of physiological and pharmacological signals. Larsson et al. describe the direct modulation of Kv7 channels by endocannabinoids and explore how combinations of Kv7 activators with distinct subtype specificities might lead to effective and selective drug cocktails. Rockefeller University Press 2020-06-02 /pmc/articles/PMC7398145/ /pubmed/32484852 http://dx.doi.org/10.1085/jgp.202012598 Text en © 2020 Kurata http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Kurata, Harley T.
Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title_full Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title_fullStr Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title_full_unstemmed Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title_short Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
title_sort chemical regulation of kv7 channels: diverse scaffolds, sites, and mechanisms of action
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398145/
https://www.ncbi.nlm.nih.gov/pubmed/32484852
http://dx.doi.org/10.1085/jgp.202012598
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