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Combining endocannabinoids with retigabine for enhanced M-channel effect and improved K(V)7 subtype selectivity

Retigabine is unique among anticonvulsant drugs by targeting the neuronal M-channel, which is composed of K(V)7.2/K(V)7.3 and contributes to the negative neuronal resting membrane potential. Unfortunately, retigabine causes adverse effects, which limits its clinical use. Adverse effects may be reduc...

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Detalles Bibliográficos
Autores principales:	Larsson, Johan E., Karlsson, Urban, Wu, Xiongyu, Liin, Sara I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398146/ https://www.ncbi.nlm.nih.gov/pubmed/32365171 http://dx.doi.org/10.1085/jgp.202012576

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