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T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome

Adipose tissue (AT) regulatory T cells (T regs) control inflammation and metabolism. Diet-induced obesity causes hyperinsulinemia and diminishes visceral AT (VAT) T reg number and function, but whether these two phenomena were mechanistically linked was unknown. Using a T reg–specific insulin recept...

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Detalles Bibliográficos
Autores principales:	Wu, Dan, Wong, Chi Kin, Han, Jonathan M., Orban, Paul C., Huang, Qing, Gillies, Jana, Mojibian, Majid, Gibson, William T., Levings, Megan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398165/ https://www.ncbi.nlm.nih.gov/pubmed/32478834 http://dx.doi.org/10.1084/jem.20191542

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