Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated secondarily to invasive cancer. Here, we report that cDC1 dysfunction instead develops in the earliest stages of preinvasive pancreatic intraepithelial neoplasia (PanIN) in the Kras(LSL-)(G12D/+) Trp53(LSL-)(R172H/+...

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Detalles Bibliográficos
Autores principales: Lin, Jeffrey H., Huffman, Austin P., Wattenberg, Max M., Walter, David M., Carpenter, Erica L., Feldser, David M., Beatty, Gregory L., Furth, Emma E., Vonderheide, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398166/
https://www.ncbi.nlm.nih.gov/pubmed/32453421
http://dx.doi.org/10.1084/jem.20190673

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