Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8(+) T cells

CD8(+) T cells are master effectors of antitumor immunity, and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to control tumor progression. We describe lipid accumulation in the TME...

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Detalles Bibliográficos
Autores principales: Manzo, Teresa, Prentice, Boone M., Anderson, Kristin G., Raman, Ayush, Schalck, Aislyn, Codreanu, Gabriela S., Nava Lauson, Carina B., Tiberti, Silvia, Raimondi, Andrea, Jones, Marissa A., Reyzer, Michelle, Bates, Breanna M., Spraggins, Jeffrey M., Patterson, Nathan H., McLean, John A., Rai, Kunal, Tacchetti, Carlo, Tucci, Sara, Wargo, Jennifer A., Rodighiero, Simona, Clise-Dwyer, Karen, Sherrod, Stacy D., Kim, Michael, Navin, Nicholas E., Caprioli, Richard M., Greenberg, Philip D., Draetta, Giulio, Nezi, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398173/
https://www.ncbi.nlm.nih.gov/pubmed/32491160
http://dx.doi.org/10.1084/jem.20191920

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