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Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement

BACKGROUND: Inflammatory responses are implicated as crucial patho-mechanisms of vascular brain malformations. Inflammation is suggested to be a key contributor to aneurysm rupture; however it is unclear whether inflammation contributes similarly to bleeding of cerebral cavernous malformations (CCMs...

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Autores principales: Petridis, Athanasios K., Suresh, Marian P., Cornelius, Jan F., Bostelmann, Richard, Dibué-Adjei, Maxine, Li, Lan, Kamp, Marcel A., Steiger, Hans Jakob, Turowski, Bernd, May, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398178/
https://www.ncbi.nlm.nih.gov/pubmed/32922871
http://dx.doi.org/10.1186/s41016-018-0116-9
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author Petridis, Athanasios K.
Suresh, Marian P.
Cornelius, Jan F.
Bostelmann, Richard
Dibué-Adjei, Maxine
Li, Lan
Kamp, Marcel A.
Steiger, Hans Jakob
Turowski, Bernd
May, Rebecca
author_facet Petridis, Athanasios K.
Suresh, Marian P.
Cornelius, Jan F.
Bostelmann, Richard
Dibué-Adjei, Maxine
Li, Lan
Kamp, Marcel A.
Steiger, Hans Jakob
Turowski, Bernd
May, Rebecca
author_sort Petridis, Athanasios K.
collection PubMed
description BACKGROUND: Inflammatory responses are implicated as crucial patho-mechanisms of vascular brain malformations. Inflammation is suggested to be a key contributor to aneurysm rupture; however it is unclear whether inflammation contributes similarly to bleeding of cerebral cavernous malformations (CCMs). Black blood MRI is a sequence which identifies inflammation in blood vessel walls and in the present study is used to detect inflammatory response in CCMs. METHODS: Fifteen patients with 17 CCMs treated in our department in 2017 were retrospectively analysed. All patients received black blood MRIs and the results were analysed in correlation with, size and bleeding of CCMs. RESULTS: Size and bleeding status of CCMs did not correlate with contrast enhancement in the CCM wall. One of 3 patients with bleeding displayed contrast enhancement in black blood MRI, whereas the others had non enhancing lesions. Because of the small number of cases a statistical analysis was not performed. CONCLUSION: In this limited cohort, inflammatory reactions in CCMs could not be detected by black blood MRI suggesting that the level of inflammation is minimal in these lesions and those different patho-mechanisms play a more important role in the rupture of CCMs.
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spelling pubmed-73981782020-09-10 Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement Petridis, Athanasios K. Suresh, Marian P. Cornelius, Jan F. Bostelmann, Richard Dibué-Adjei, Maxine Li, Lan Kamp, Marcel A. Steiger, Hans Jakob Turowski, Bernd May, Rebecca Chin Neurosurg J Research BACKGROUND: Inflammatory responses are implicated as crucial patho-mechanisms of vascular brain malformations. Inflammation is suggested to be a key contributor to aneurysm rupture; however it is unclear whether inflammation contributes similarly to bleeding of cerebral cavernous malformations (CCMs). Black blood MRI is a sequence which identifies inflammation in blood vessel walls and in the present study is used to detect inflammatory response in CCMs. METHODS: Fifteen patients with 17 CCMs treated in our department in 2017 were retrospectively analysed. All patients received black blood MRIs and the results were analysed in correlation with, size and bleeding of CCMs. RESULTS: Size and bleeding status of CCMs did not correlate with contrast enhancement in the CCM wall. One of 3 patients with bleeding displayed contrast enhancement in black blood MRI, whereas the others had non enhancing lesions. Because of the small number of cases a statistical analysis was not performed. CONCLUSION: In this limited cohort, inflammatory reactions in CCMs could not be detected by black blood MRI suggesting that the level of inflammation is minimal in these lesions and those different patho-mechanisms play a more important role in the rupture of CCMs. BioMed Central 2018-05-08 /pmc/articles/PMC7398178/ /pubmed/32922871 http://dx.doi.org/10.1186/s41016-018-0116-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Petridis, Athanasios K.
Suresh, Marian P.
Cornelius, Jan F.
Bostelmann, Richard
Dibué-Adjei, Maxine
Li, Lan
Kamp, Marcel A.
Steiger, Hans Jakob
Turowski, Bernd
May, Rebecca
Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title_full Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title_fullStr Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title_full_unstemmed Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title_short Cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement
title_sort cavernous brain malformations and their relation to black blood mri in respect to vessel wall contrast enhancement
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398178/
https://www.ncbi.nlm.nih.gov/pubmed/32922871
http://dx.doi.org/10.1186/s41016-018-0116-9
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