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Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report
BACKGROUND: As chordomas are slow growing and locally invasive with high recurrence rates, initial recommendations include complete surgical resection with or without radiation therapy. A large proportion of recurrences occur years after initial resection necessitating lengthy follow-up. The novel b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398216/ https://www.ncbi.nlm.nih.gov/pubmed/32922921 http://dx.doi.org/10.1186/s41016-019-0170-y |
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author | Rotter, Juliana Mueller, Kyle MacConnell, Ashley McGowan, Jason Spitz, Steven |
author_facet | Rotter, Juliana Mueller, Kyle MacConnell, Ashley McGowan, Jason Spitz, Steven |
author_sort | Rotter, Juliana |
collection | PubMed |
description | BACKGROUND: As chordomas are slow growing and locally invasive with high recurrence rates, initial recommendations include complete surgical resection with or without radiation therapy. A large proportion of recurrences occur years after initial resection necessitating lengthy follow-up. The novel biomarker brachyury and the repurposing of pharmaceutical products have the potential to substantially impact long-term recurrence rates. CASE PRESENTATION: A 43-year-old woman presented with an isolated, cervical extraosseous intradural extramedullary chordoma attached to a nerve root underwent a C3-5 laminectomy, C3-5 lateral mass screw instrumentation, and mass resection. All symptoms resolved by the 12-month postoperative follow-up visit. CONCLUSIONS: This is the first report of an isolated, cervical extraosseous intradural extramedullary chordoma attached to a nerve root, and this case adds to the previous six Type IV chordomas in the literature. Unfortunately, the very rare form of extraosseous intradural chordoma is poorly understood: the lack of detailed knowledge in how they are differentiated from other forms of chordoma confounds the development of optimal treatment strategies and follow-up guidelines. |
format | Online Article Text |
id | pubmed-7398216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73982162020-09-10 Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report Rotter, Juliana Mueller, Kyle MacConnell, Ashley McGowan, Jason Spitz, Steven Chin Neurosurg J Case Report BACKGROUND: As chordomas are slow growing and locally invasive with high recurrence rates, initial recommendations include complete surgical resection with or without radiation therapy. A large proportion of recurrences occur years after initial resection necessitating lengthy follow-up. The novel biomarker brachyury and the repurposing of pharmaceutical products have the potential to substantially impact long-term recurrence rates. CASE PRESENTATION: A 43-year-old woman presented with an isolated, cervical extraosseous intradural extramedullary chordoma attached to a nerve root underwent a C3-5 laminectomy, C3-5 lateral mass screw instrumentation, and mass resection. All symptoms resolved by the 12-month postoperative follow-up visit. CONCLUSIONS: This is the first report of an isolated, cervical extraosseous intradural extramedullary chordoma attached to a nerve root, and this case adds to the previous six Type IV chordomas in the literature. Unfortunately, the very rare form of extraosseous intradural chordoma is poorly understood: the lack of detailed knowledge in how they are differentiated from other forms of chordoma confounds the development of optimal treatment strategies and follow-up guidelines. BioMed Central 2019-09-09 /pmc/articles/PMC7398216/ /pubmed/32922921 http://dx.doi.org/10.1186/s41016-019-0170-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Rotter, Juliana Mueller, Kyle MacConnell, Ashley McGowan, Jason Spitz, Steven Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title | Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title_full | Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title_fullStr | Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title_full_unstemmed | Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title_short | Isolated cervical extraosseous intradural chordoma attached to the C5 nerve root: a case report |
title_sort | isolated cervical extraosseous intradural chordoma attached to the c5 nerve root: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398216/ https://www.ncbi.nlm.nih.gov/pubmed/32922921 http://dx.doi.org/10.1186/s41016-019-0170-y |
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