The interplay between immunosenescence and age-related diseases

The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28(−)), regulatory...

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Autores principales: Barbé-Tuana, Florencia, Funchal, Giselle, Schmitz, Carine Raquel Richter, Maurmann, Rafael Moura, Bauer, Moisés E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398288/
https://www.ncbi.nlm.nih.gov/pubmed/32747977
http://dx.doi.org/10.1007/s00281-020-00806-z
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author Barbé-Tuana, Florencia
Funchal, Giselle
Schmitz, Carine Raquel Richter
Maurmann, Rafael Moura
Bauer, Moisés E.
author_facet Barbé-Tuana, Florencia
Funchal, Giselle
Schmitz, Carine Raquel Richter
Maurmann, Rafael Moura
Bauer, Moisés E.
author_sort Barbé-Tuana, Florencia
collection PubMed
description The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28(−)), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.
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spelling pubmed-73982882020-08-04 The interplay between immunosenescence and age-related diseases Barbé-Tuana, Florencia Funchal, Giselle Schmitz, Carine Raquel Richter Maurmann, Rafael Moura Bauer, Moisés E. Semin Immunopathol Review The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28(−)), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases. Springer Berlin Heidelberg 2020-08-03 2020 /pmc/articles/PMC7398288/ /pubmed/32747977 http://dx.doi.org/10.1007/s00281-020-00806-z Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Barbé-Tuana, Florencia
Funchal, Giselle
Schmitz, Carine Raquel Richter
Maurmann, Rafael Moura
Bauer, Moisés E.
The interplay between immunosenescence and age-related diseases
title The interplay between immunosenescence and age-related diseases
title_full The interplay between immunosenescence and age-related diseases
title_fullStr The interplay between immunosenescence and age-related diseases
title_full_unstemmed The interplay between immunosenescence and age-related diseases
title_short The interplay between immunosenescence and age-related diseases
title_sort interplay between immunosenescence and age-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398288/
https://www.ncbi.nlm.nih.gov/pubmed/32747977
http://dx.doi.org/10.1007/s00281-020-00806-z
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