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Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis
OBJECTIVE: We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic). METHODS: We prospectively assessed the med...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398466/ https://www.ncbi.nlm.nih.gov/pubmed/32354798 http://dx.doi.org/10.1136/heartjnl-2020-317007 |
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author | Wei, Jia-Fu Huang, Fang-Yang Xiong, Tian-Yuan Liu, Qi Chen, Hong Wang, Hui Huang, He Luo, Yi-Chun Zhou, Xuan Liu, Zhi-Yue Peng, Yong Xu, Yuan-Ning Wang, Bo Yang, Ying-Ying Liang, Zong-An Lei, Xue-Zhong Ge, Yang Yang, Ming Zhang, Ling Zeng, Ming-Quan Yu, He Liu, Kai Jia, Yu-Heng Prendergast, Bernard D Li, Wei-Min Chen, Mao |
author_facet | Wei, Jia-Fu Huang, Fang-Yang Xiong, Tian-Yuan Liu, Qi Chen, Hong Wang, Hui Huang, He Luo, Yi-Chun Zhou, Xuan Liu, Zhi-Yue Peng, Yong Xu, Yuan-Ning Wang, Bo Yang, Ying-Ying Liang, Zong-An Lei, Xue-Zhong Ge, Yang Yang, Ming Zhang, Ling Zeng, Ming-Quan Yu, He Liu, Kai Jia, Yu-Heng Prendergast, Bernard D Li, Wei-Min Chen, Mao |
author_sort | Wei, Jia-Fu |
collection | PubMed |
description | OBJECTIVE: We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic). METHODS: We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. Acute myocardial injury was defined by a value of high-sensitivity troponin T (hs-TnT) greater than the normal upper limit. RESULTS: A total of 101 cases were enrolled from January to 10 March 2020 (average age 49 years, IQR 34–62 years). Acute myocardial injury was present in 15.8% of patients, nearly half of whom had a hs-TnT value fivefold greater than the normal upper limit. Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). Log hs-TnT was associated with disease severity (OR 6.63, 95% CI 2.24 to 19.65), and all of the three deaths occurred in patients with acute myocardial injury. CONCLUSION: Acute myocardial injury is common in patients with COVID-19 and is associated with adverse prognosis. |
format | Online Article Text |
id | pubmed-7398466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-73984662020-08-17 Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis Wei, Jia-Fu Huang, Fang-Yang Xiong, Tian-Yuan Liu, Qi Chen, Hong Wang, Hui Huang, He Luo, Yi-Chun Zhou, Xuan Liu, Zhi-Yue Peng, Yong Xu, Yuan-Ning Wang, Bo Yang, Ying-Ying Liang, Zong-An Lei, Xue-Zhong Ge, Yang Yang, Ming Zhang, Ling Zeng, Ming-Quan Yu, He Liu, Kai Jia, Yu-Heng Prendergast, Bernard D Li, Wei-Min Chen, Mao Heart Special Populations OBJECTIVE: We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic). METHODS: We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. Acute myocardial injury was defined by a value of high-sensitivity troponin T (hs-TnT) greater than the normal upper limit. RESULTS: A total of 101 cases were enrolled from January to 10 March 2020 (average age 49 years, IQR 34–62 years). Acute myocardial injury was present in 15.8% of patients, nearly half of whom had a hs-TnT value fivefold greater than the normal upper limit. Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). Log hs-TnT was associated with disease severity (OR 6.63, 95% CI 2.24 to 19.65), and all of the three deaths occurred in patients with acute myocardial injury. CONCLUSION: Acute myocardial injury is common in patients with COVID-19 and is associated with adverse prognosis. BMJ Publishing Group 2020-08 2020-04-30 /pmc/articles/PMC7398466/ /pubmed/32354798 http://dx.doi.org/10.1136/heartjnl-2020-317007 Text en © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage |
spellingShingle | Special Populations Wei, Jia-Fu Huang, Fang-Yang Xiong, Tian-Yuan Liu, Qi Chen, Hong Wang, Hui Huang, He Luo, Yi-Chun Zhou, Xuan Liu, Zhi-Yue Peng, Yong Xu, Yuan-Ning Wang, Bo Yang, Ying-Ying Liang, Zong-An Lei, Xue-Zhong Ge, Yang Yang, Ming Zhang, Ling Zeng, Ming-Quan Yu, He Liu, Kai Jia, Yu-Heng Prendergast, Bernard D Li, Wei-Min Chen, Mao Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title | Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title_full | Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title_fullStr | Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title_full_unstemmed | Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title_short | Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis |
title_sort | acute myocardial injury is common in patients with covid-19 and impairs their prognosis |
topic | Special Populations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398466/ https://www.ncbi.nlm.nih.gov/pubmed/32354798 http://dx.doi.org/10.1136/heartjnl-2020-317007 |
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