DNA clamp function of the mono-ubiquitinated Fanconi Anemia ID complex

The FANCI-FANCD2 (ID) complex, mutated in the Fanconi Anemia (FA) cancer predisposition syndrome, is required for the repair of interstrand crosslinks (ICL) and related lesions(1). The FA pathway is activated when a replication fork stalls at an ICL(2), triggering the mono-ubiquitination of the ID c...

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Detalles Bibliográficos
Autores principales: Wang, Renjing, Wang, Shengliu, Dhar, Ankita, Peralta, Christopher, Pavletich, Nikola P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398534/
https://www.ncbi.nlm.nih.gov/pubmed/32269332
http://dx.doi.org/10.1038/s41586-020-2110-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398534/
https://www.ncbi.nlm.nih.gov/pubmed/32269332
http://dx.doi.org/10.1038/s41586-020-2110-6

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