Cargando…

Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany

The COVID-19 pandemic has led to an unprecedented world-wide effort to gather data, model, and understand the viral spread. Entire societies and economies are desperate to recover and get back to normality. However, to this end accurate models are of essence that capture both the viral spread and th...

Descripción completa

Detalles Bibliográficos
Autores principales: Kergaßner, Andreas, Burkhardt, Christian, Lippold, Dorothee, Kergaßner, Matthias, Pflug, Lukas, Budday, Dominik, Steinmann, Paul, Budday, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398641/
https://www.ncbi.nlm.nih.gov/pubmed/32836600
http://dx.doi.org/10.1007/s00466-020-01883-5
_version_ 1783565992112160768
author Kergaßner, Andreas
Burkhardt, Christian
Lippold, Dorothee
Kergaßner, Matthias
Pflug, Lukas
Budday, Dominik
Steinmann, Paul
Budday, Silvia
author_facet Kergaßner, Andreas
Burkhardt, Christian
Lippold, Dorothee
Kergaßner, Matthias
Pflug, Lukas
Budday, Dominik
Steinmann, Paul
Budday, Silvia
author_sort Kergaßner, Andreas
collection PubMed
description The COVID-19 pandemic has led to an unprecedented world-wide effort to gather data, model, and understand the viral spread. Entire societies and economies are desperate to recover and get back to normality. However, to this end accurate models are of essence that capture both the viral spread and the courses of disease in space and time at reasonable resolution. Here, we combine a spatially resolved county-level infection model for Germany with a memory-based integro-differential approach capable of directly including medical data on the course of disease, which is not possible when using traditional SIR-type models. We calibrate our model with data on cumulative detected infections and deaths from the Robert-Koch Institute and demonstrate how the model can be used to obtain county- or even city-level estimates on the number of new infections, hospitality rates and demands on intensive care units. We believe that the present work may help guide decision makers to locally fine-tune their expedient response to potential new outbreaks in the near future.
format Online
Article
Text
id pubmed-7398641
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-73986412020-08-04 Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany Kergaßner, Andreas Burkhardt, Christian Lippold, Dorothee Kergaßner, Matthias Pflug, Lukas Budday, Dominik Steinmann, Paul Budday, Silvia Comput Mech Original Paper The COVID-19 pandemic has led to an unprecedented world-wide effort to gather data, model, and understand the viral spread. Entire societies and economies are desperate to recover and get back to normality. However, to this end accurate models are of essence that capture both the viral spread and the courses of disease in space and time at reasonable resolution. Here, we combine a spatially resolved county-level infection model for Germany with a memory-based integro-differential approach capable of directly including medical data on the course of disease, which is not possible when using traditional SIR-type models. We calibrate our model with data on cumulative detected infections and deaths from the Robert-Koch Institute and demonstrate how the model can be used to obtain county- or even city-level estimates on the number of new infections, hospitality rates and demands on intensive care units. We believe that the present work may help guide decision makers to locally fine-tune their expedient response to potential new outbreaks in the near future. Springer Berlin Heidelberg 2020-08-03 2020 /pmc/articles/PMC7398641/ /pubmed/32836600 http://dx.doi.org/10.1007/s00466-020-01883-5 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Kergaßner, Andreas
Burkhardt, Christian
Lippold, Dorothee
Kergaßner, Matthias
Pflug, Lukas
Budday, Dominik
Steinmann, Paul
Budday, Silvia
Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title_full Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title_fullStr Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title_full_unstemmed Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title_short Memory-based meso-scale modeling of Covid-19: County-resolved timelines in Germany
title_sort memory-based meso-scale modeling of covid-19: county-resolved timelines in germany
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398641/
https://www.ncbi.nlm.nih.gov/pubmed/32836600
http://dx.doi.org/10.1007/s00466-020-01883-5
work_keys_str_mv AT kergaßnerandreas memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT burkhardtchristian memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT lippolddorothee memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT kergaßnermatthias memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT pfluglukas memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT buddaydominik memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT steinmannpaul memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany
AT buddaysilvia memorybasedmesoscalemodelingofcovid19countyresolvedtimelinesingermany