Cargando…

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

BACKGROUND: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. OBJECTIVES: We aimed to investigate the effects of 6 wk NR supplementation on insulin sensitivity, mito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Remie, Carlijn M E, Roumans, Kay H M, Moonen, Michiel P B, Connell, Niels J, Havekes, Bas, Mevenkamp, Julian, Lindeboom, Lucas, de Wit, Vera H W, van de Weijer, Tineke, Aarts, Suzanne A B M, Lutgens, Esther, Schomakers, Bauke V, Elfrink, Hyung L, Zapata-Pérez, Rubén, Houtkooper, Riekelt H, Auwerx, Johan, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Phielix, Esther, Schrauwen, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398770/ https://www.ncbi.nlm.nih.gov/pubmed/32320006 http://dx.doi.org/10.1093/ajcn/nqaa072

Ejemplares similares

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial
por: Bruls, Yvonne MH, et al.
Publicado: (2019)

Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial
por: Andriessen, Charlotte, et al.
Publicado: (2022)

Metabolic responses to mild cold acclimation in type 2 diabetes patients
por: Remie, Carlijn M. E., et al.
Publicado: (2021)

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility
por: Bruls, Yvonne M. H., et al.
Publicado: (2020)

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women
por: Remie, Carlijn M. E., et al.
Publicado: (2021)

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
por: Phielix, Esther, et al.
Publicado: (2008)

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity
por: Meex, Ruth C.R., et al.
Publicado: (2010)

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial
por: de Ligt, Marlies, et al.
Publicado: (2020)

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
por: Roumans, Kay H. M., et al.
Publicado: (2020)

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
por: Vanweert, Froukje, et al.
Publicado: (2022)

Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions
por: Basset-Sagarminaga, Jeremy, et al.
Publicado: (2023)

Liver fat storage pathways: methodologies and dietary effects
por: Roumans, Kay H.M., et al.
Publicado: (2021)

Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus
por: van de Weijer, Tineke, et al.
Publicado: (2013)

NAD(+)-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults
por: Connell, N J, et al.
Publicado: (2021)

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes
por: de Ligt, Marlies, et al.
Publicado: (2018)

Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans
por: Mancilla, Rodrigo, et al.
Publicado: (2020)

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension
por: Bilet, Lena, et al.
Publicado: (2020)

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans
por: van de Weijer, Tineke, et al.
Publicado: (2015)

A metabolomic signature of decelerated physiological aging in human plasma
por: Janssens, Georges E., et al.
Publicado: (2023)

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans
por: Mancilla, Rodrigo F., et al.
Publicado: (2023)

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups
por: Dahlmans, Dennis, et al.
Publicado: (2017)

Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect (13)C measurements in the human liver
por: Veeraiah, Pandichelvam, et al.
Publicado: (2020)

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function
por: Grevendonk, L., et al.
Publicado: (2021)

NAD(+) metabolism as a target for metabolic health: have we found the silver bullet?
por: Connell, Niels J., et al.
Publicado: (2019)

Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism
por: op den Kamp, Yvo J.M., et al.
Publicado: (2022)

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
por: Phielix, Esther, et al.
Publicado: (2012)

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
por: de Wit-Verheggen, Vera H. W., et al.
Publicado: (2023)

Effects of exercise training on intrahepatic lipid content in humans
por: Brouwers, Bram, et al.
Publicado: (2016)

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
por: Vanweert, Froukje, et al.
Publicado: (2022)

Relationship of C5L2 Receptor to Skeletal Muscle Substrate Utilization
por: Roy, Christian, et al.
Publicado: (2013)

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity
por: Vanweert, Froukje, et al.
Publicado: (2021)

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity
por: Sparks, Lauren M., et al.
Publicado: (2016)

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity
por: van Moorsel, Dirk, et al.
Publicado: (2016)

Exploring the therapeutic space around NAD(+)
por: Houtkooper, Riekelt H., et al.
Publicado: (2012)

Invasive and noninvasive markers of human skeletal muscle mitochondrial function
por: Mancilla, Rodrigo, et al.
Publicado: (2023)

Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals
por: Wefers, Jakob, et al.
Publicado: (2020)

Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men
por: Wulan, Siti N., et al.
Publicado: (2015)

Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial
por: van Beek, Sten M. M., et al.
Publicado: (2023)

Passive exposure to heat improves glucose metabolism in overweight humans
por: Pallubinsky, Hannah, et al.
Publicado: (2020)

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
por: Phielix, E., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ebdmqae5acjq4qpvruc69p1opg