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High-Dimensional Design-Of-Experiments Extracts Small-Molecule-Only Induction Conditions for Dorsal Pancreatic Endoderm from Pluripotency

The derivation of endoderm and descendant organs, such as pancreas, liver, and intestine, impacts disease modeling and regenerative medicine. Use of TGF-β signaling agonism is a common method for induction of definitive endoderm from pluripotency. By using a data-driven, High-Dimensional Design of E...

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Detalles Bibliográficos
Autores principales:	Bukys, Michael A., Mihas, Alexander, Finney, Krystal, Sears, Katie, Trivedi, Divya, Wang, Yong, Oberholzer, Jose, Jensen, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398937/ https://www.ncbi.nlm.nih.gov/pubmed/32745983 http://dx.doi.org/10.1016/j.isci.2020.101346

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